Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Perineural vs intravenous dexamethasone

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · peripheral nerve block
3 findings from 1 review

Perineural dexamethasone vs placebo

Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Summary of findings for the main comparison: cough augmentation techniques vs no cough augmentation technique

Adverse events 1. Hypotensionc 2. Hypertensiond 3. Secretion encumbrance resulting in severe hypoxaemia requiring reintubationc · critically‐ill mechanically‐ventilated adults and children requiring extubation from mechanical ventilation

It is very uncertain whether summary of findings for the main comparison: cough augmentation… changes adverse events 1. Hypotensionc 2. Hypertensiond 3. Secretion… compared with no cough augmentation technique (very low certainty).

1 finding from 1 review

Cuffed vs uncuffed tubes

Need for intensive care unit (ICU) admission to treat post extubation stridor (as defined by the trial authors) · Children up to eight years undergoing general anaesthesia

It is very uncertain whether cuffed changes need for intensive care unit (ICU) admission to treat post… compared with uncuffed tubes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Hypertensive disorders of pregnancy · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes hypertensive disorders of pregnancy ‐ (any type) compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Lifestyle interventions vs control ‐ Maternal outcomes

Hypertensive disorders of pregnancy: pre‐eclampsia · women with gestational diabetes mellitus

Lifestyle interventions showed no clear difference in hypertensive disorders of pregnancy (pre‐eclampsia) compared with control ‐ Maternal outcomes (low certainty).

1 finding from 1 review

Acupuncture vs treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review