Question · asked by 1 review
Metformin vs glibenclamide ‐ maternal outcomes: Hypertensive disorders of pregnancy
- Population
- women with gestational diabetes mellitus
- Intervention
- Metformin
- Comparison
- glibenclamide ‐ maternal outcomes
- Outcome
- Hypertensive disorders of pregnancy
Metformin showed no clear difference in hypertensive disorders of pregnancy compared with glibenclamide ‐ maternal outcomes (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Metformin vs glibenclamide ‐ maternal outcomes Hypertensive disorders of pregnancy · women diagnosed with gestational diabetes Metformin showed no clear difference in hypertensive disorders of pregnancy compared with glibenclamide ‐ maternal outcomes (moderate certainty). Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes (2017) · Cochrane Headline outcomes only | RR 0.7 [0.38, 1.3] | 3 studies · 508 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.