Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in chronic herpes simplex infection between ART regimens (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No eligible studies compared oral hairy leukoplakia between different ART regimens.

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).

1 finding from 1 review

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Dental caries prevalence · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
  • Milsom 2006 measured prevalence of dental caries as mean number of teeth with active caries in primary teeth (dt) and permanent teeth (DT); post-intervention changes from baseline were not significant, and the authors…
    1 study · 16684 participants
    GRADE not reported

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in gingivitis between ART regimens (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in chronic herpes simplex infection between CLWH with and without ART (very low certainty).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).

1 finding from 1 review

Food marketing exposure or greater marketing power vs No, less, or less powerful food marketing

Food preference · Children and adolescents (general population, aged under 20 years)

In crossover studies with binary outcomes, food marketing increased food preference (OR 3.49, 95% CI 2.03 to 6.22; ungraded).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in persistent parotid enlargement between ART regimens (very low certainty).

1 finding from 1 review

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Reported incidence or prevalence of root resorption of the impacted canine and/or incisors and/or first premolars · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Visual examination (VE) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, visual examination pooled summary ROC AUC was 0.70 for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
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Laser fluorescence (DIAGNOdent 2095) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, laser fluorescence (DIAGNOdent 2095) pooled diagnostic odds ratio was 18.33 (95% CI 7.57 to 44.37) for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
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