Pulp necrosis · Vital teeth
The pooled incidence with ≤ 5 years of follow-up was 3.53%.
1 finding from 1 review
Lightness change · Patients with post-orthodontic white spot lesions and permanent dentition
Knosel (2019) reported a statistically significant lightness-change effect.
3 findings from 1 review
Cohen's d 0.71 [0.32, 1.09]
1 study
GRADE not reported
Cohen's d -1.76 [-2.22, -1.30]
1 study
GRADE not reported
Cohen's d 0.40 [0.11, 0.65]
1 study
GRADE not reported
Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH)
Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).
1 finding from 1 review
Food intake · Children and adolescents (general population, aged under 20 years)
Food marketing was associated with a significant increase in children's food intake (pooled SMD, 0.25; combined RCT and nonrandomized evidence).
3 findings from 1 review
DMFS (decayed, missing, filled surfaces) increment, occlusal surfaces · Schoolchildren aged 6-12 years with sound occlusal surfaces of the first permanent molars
Pit and fissure sealant and fluoride varnish showed no statistically significant difference in DMFS increment at 24 months (SMD -0.13, 95% CI -0.67 to 0.40; I2=92%; not GRADE-rated).
1 finding from 1 review
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Responsive complementary feeding probably reduces the risk of overweight/obesity versus other feeding models (RR 0.41, 95% CI 0.24 to 0.71; moderate certainty).
1 finding from 1 review
Intervention not reported
Adverse events
1 finding from 1 review
Dental caries prevalence · 12-year-old children (permanent dentition) in Africa
Pooled caries prevalence in Uganda was 0.27 (95% CI 0.126 to 0.418; 3 article(s); not GRADE-rated).
23 findings from 1 review
Prevalence 0.27 [0.126, 0.418]
3 studies
GRADE not reported
Prevalence 0.329 [0.111, 0.548]
3 studies
GRADE not reported
Prevalence 0.282 [0.227, 0.337]
13 studies
GRADE not reported
Show 20 more findings
Prevalence 0.13 [0.106, 0.163]
2 studies
GRADE not reported
Prevalence 0.78 [0.724, 0.831]
1 study
GRADE not reported
Prevalence 0.34 [0.276, 0.401]
5 studies
GRADE not reported
Prevalence 0.48 [0.45, 0.514]
1 study
GRADE not reported
Prevalence 0.391 [0.305, 0.477]
10 studies
GRADE not reported
Prevalence 0.36 [0.294, 0.417]
25 studies · 18080 participants
GRADE not reported
Prevalence 0.314 [0.186, 0.443]
10 studies
GRADE not reported
Prevalence 0.30 [0.239, 0.375]
1 study
GRADE not reported
Prevalence 0.49 [0.42, 0.568]
1 study
GRADE not reported
Prevalence 0.73 [0.694, 0.759]
1 study
GRADE not reported
Prevalence 0.31 [0.279, 0.333]
1 study
GRADE not reported
Prevalence 0.346 [0.085, 0.606]
3 studies
GRADE not reported
Prevalence 0.29 [0.247, 0.326]
1 study
GRADE not reported
Prevalence 0.33 [0.066, 0.584]
3 studies
GRADE not reported
Prevalence 0.574 [0.427, 0.721]
5 studies
GRADE not reported
Prevalence 0.34 [0.299, 0.376]
2 studies
GRADE not reported
Prevalence 0.59 [0.523, 0.654]
1 study
GRADE not reported
Prevalence 0.11 [0.045, 0.26]
1 study
GRADE not reported
Prevalence 0.403 [0.233, 0.574]
7 studies
GRADE not reported
Prevalence 0.19 [0.168, 0.214]
1 study
GRADE not reported
Dental caries prevalence · European adolescents aged 15 years
Pooled caries prevalence was 0.77 (I² = 97.9%).
1 finding from 1 review
Dental caries prevalence and severity · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in dental caries/severity between ART regimens (very low certainty).
1 finding from 1 review
Enamel caries proportion · European adolescents aged 15 years
Pooled enamel caries proportion was 0.72 (I² = 99.8%).
1 finding from 1 review
Kaposi's sarcoma (WHO clinical stage 4) · Children or adolescents
No eligible studies reported Kaposi's sarcoma.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Among 6 observational studies, pooled pulpotomy success was 92.6 per 100 (95% CI 0.86-0.96), very low certainty.
4 findings from 1 review
Show 1 more finding
Z score BMI · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
In one RCT, responsive complementary feeding lowered BMIz at 13 months versus control (0.23 vs 0.42, p=0.01; low certainty).
1 finding from 1 review
Risk of overweight and obesity after 13 mo (RCT, BMIz): DANIELS 2012 - children in the intervention group had a lower BMIz at 13 months than controls (0.23 +/- 0.93 vs 0.42 +/- 0.85; p = 0.01); 698 (1 RCT); Low.
1 study · 698 participants
Low
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
CEM and calcium hydroxide did not differ significantly in pulpotomy success (indirect comparison); ungraded.
1 finding from 1 review
Salivary immunoglobulin A (SIgA) concentration · Children or adolescents
No significant difference in total salivary IgA between CLWH and healthy controls, though anti-Candida SIgA was higher in HIV groups; narrative only.
1 finding from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal)
Pomarico 2009 reported no significant difference in total SIgA among HIV-ART, HIV-HAART, and healthy children, but significantly higher anti-Candida albicans SIgA in the two HIV groups; no effect estimate pooled.
1 study
GRADE not reported
Food choice · Children and adolescents (general population, aged under 20 years)
In crossover studies with binary outcomes, food marketing had no clear association with food choice (OR 3.45, 95% CI 0.97 to 12.43; ungraded).
1 finding from 1 review
OR 3.45 [0.97, 12.43]
3 studies
GRADE not reported
Dental caries · 12-year-old children (permanent dentition) in Africa
Pooled mean DMFT in Sudan was 0.49 (95% CI 0.461 to 0.519; 1 article(s); not GRADE-rated).
22 findings from 1 review
Show 19 more findings
MEAN 0.91 [0.295, 1.525]
3 studies
GRADE not reported
MEAN 1.69 [1.463, 1.917]
1 study
GRADE not reported
MEAN 0.994 [0.731, 1.257]
14 studies
GRADE not reported
MEAN 1.802 [1.492, 2.111]
6 studies
GRADE not reported
MEAN 1.005 [0.797, 1.212]
10 studies
GRADE not reported
MEAN 0.61 [0.314, 0.902]
2 studies
GRADE not reported
MEAN 1.133 [0.863, 1.404]
11 studies
GRADE not reported
MEAN 0.81 [0.646, 0.979]
3 studies
GRADE not reported
MEAN 0.98 [0.829, 1.121]
1 study
GRADE not reported
MEAN 2.27 [1.931, 2.609]
1 study
GRADE not reported
MEAN 0.580 [0.320, 0.841]
5 studies
GRADE not reported
MEAN 0.60 [0.372, 0.833]
4 studies
GRADE not reported
MEAN 1.09 [0.914, 1.266]
28 studies
GRADE not reported
MEAN 2.50 [2.173, 2.827]
1 study
GRADE not reported
MEAN 1.13 [0.795, 1.454]
6 studies
GRADE not reported
MEAN 1.085 [-0.092, 2.260]
2 studies
GRADE not reported
MEAN 0.70 [0.639, 0.761]
1 study
GRADE not reported
MEAN 1.63 [1.509, 1.747]
1 study
GRADE not reported
MEAN 0.67 [0.631, 0.709]
1 study
GRADE not reported
Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in linear gingival erythema between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.29 [0.58, 2.88]
Studies not reported
Very low
Dental caries prevalence · European adolescents aged 12 years
Pooled caries prevalence was 0.49 (I² = 99.9%).
1 finding from 1 review