Question · asked by 1 review
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive): Salivary immunoglobulin A (SIgA) concentration
- Population
- Children and adolescents (<18 years) living with HIV (CLWH)
- Intervention
- Antiretroviral therapy (any, including cART)
- Comparison
- No antiretroviral medication (treatment-naive)
- Outcome
- Salivary immunoglobulin A (SIgA) concentration
Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH) · Hospitals and AIDS outpatient centres in India, Brazil, and several Asian countries Evidence on salivary IgA in CLWH on versus off ART was divergent and inconclusive (very low certainty). Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) All outcomes | Two studies gave divergent results: Subramaniam (2015) reported higher SIgA in children on ART for more than 3 years than pre-ART (8.6 (SD 2.9) vs 6.2 (SD 1.7) mg/dL; p < 0.001), whereas Pomarico (2009) found lower… | 2 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis. 2022 All outcomes | 2022-08-03 (inception to 3 August 2022) | 14 | Critically Low / Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.