Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Need for extra treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis

Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Surgical site infections: liver transplant recipients Time frame: 30 days · solid organ transplant recipients

It is very uncertain whether extended changes surgical site infections: liver transplant recipients Time frame: 30… compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Graft loss including death · solid organ transplant recipients

It is very uncertain whether extended changes graft loss (including death with functioning graft) Time frame: 30… compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Other infection: septicaemia Time frame: 2 to 6 weeks · solid organ transplant recipients

It is very uncertain whether extended changes other infection: septicaemia Time frame: 30 days compared with short duration antibiotics (very low certainty).

1 finding from 1 review

Extended vs short duration antibiotics

Other infection: pneumonia Time frame: 30 days · solid organ transplant recipients

It is very uncertain whether extended changes other infection: pneumonia Time frame: 30 days compared with short duration antibiotics (very low certainty).

1 finding from 1 review