Cochrane · systematic review · CD013209
Perioperative antibiotics for preventing post‐surgical site infections in solid organ transplant recipients
Chan, S, Ng, S, Chan, HP, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
14
No studies
2
Included studies
NR
No studies 2 · 12.5%Ungraded 0 · 0%Very low 14 · 87.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics versus no antibiotics for preventing post‐surgical site infections in solid organ transplant recipients
Population: solid organ transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Surgical site infections* Time frame: 2 to 6 weeks Antibiotics vs no antibiotics | RR 0.42 [0.21, 0.85] | 5 studies · 226 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Death (any case) Time frame: 2 to 4 weeks Antibiotics vs no antibiotics | RR 0.27 [0.02, 3.69] | 2 studies · 87 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Graft loss (including death with functioning graft) Time frame: 2 weeks Antibiotics vs no antibiotics | RR 2.89 [0.12, 67.96] | 1 study · 53 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: UTI Time frame: 2 to 6 weeks Antibiotics vs no antibiotics | RR 0.88 [0.68, 1.14] | 3 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: septicaemia Time frame: 2 to 6 weeks Antibiotics vs no antibiotics | RR 0.5 [0.11, 2.19] | 2 studies · 90 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: pneumonia Time frame: up to 6 weeks Antibiotics vs no antibiotics | RR 0.53 [0.21, 1.32] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse reactions Antibiotics vs no antibiotics | no estimate extracted | NR | No studies |
Extended versus short duration antibiotics for preventing post‐surgical site infections in solid organ transplant recipients
Population: preventing post‐surgical site infections in solid organ transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Surgical site infections* (all) Time frame: 30 days Extended vs short duration antibiotics | RR 1.19 [0.58, 2.48] | 2 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Surgical site infections: kidney transplant recipients Time frame: 30 days Extended vs short duration antibiotics | RR 0.5 [0.05, 5.48] | 1 study · 205 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Surgical site infections: liver transplant recipients Time frame: 30 days Extended vs short duration antibiotics | RR 1.31 [0.61, 2.81] | 1 study · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Death (any cause) Time frame: 30 days Extended vs short duration antibiotics | RR 0.2 [0.01, 3.98] | 1 study · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Graft loss (including death with functioning graft) Time frame: 30 days Extended vs short duration antibiotics | RR 0.99 [0.49, 2] | 2 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: UTI Time frame: 30 days Extended vs short duration antibiotics | RR 0.49 [0.13, 1.85] | 1 study · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: septicaemia Time frame: 30 days Extended vs short duration antibiotics | RR 0.9 [0.51, 1.58] | 2 studies · 302 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other infection: pneumonia Time frame: 30 days Extended vs short duration antibiotics | RR 10.78 [0.61, 189.77] | 1 study · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse reactions Extended vs short duration antibiotics | no estimate extracted | NR | No studies |