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What do systematic reviews say?

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Evidence found and GRADE certainty

416 questions · 426 findings · 56 reviews

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No studies found 109 · 25.6%GRADE not reported 23 · 5.4%Very low 109 · 25.6%Low 106 · 24.9%Moderate 64 · 15%High 15 · 3.5%

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulant vs control

Symptomatic PE · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant leads to lower symptomatic pulmonary embolism during treatment period compared with control (high certainty).

1 finding from 1 review

Anticoagulant vs control

Major extracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher major extracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Pulmonary exacerbations number of participants requiring IV antibiotics · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in pulmonary exacerbations number of participants requiring IV… compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Immunoglobulin vs placebo

Mortality (any cause during hospitalisation or · children with respiratory syncytial virus infection

It is very uncertain whether summary of findings table ‐ Immunoglobulins changes mortality (any cause during hospitalisation or compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ immunostimulant vs placebo

Participants with no exacerbations in study period · adults with chronic bronchitis or chronic obstructive pulmonary disease

Summary of findings table ‐ immunostimulant probably leads to higher number of participants with no exacerbations during the study period compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ immunostimulant vs placebo

Number of participants requiring antibiotics · adults with chronic bronchitis or chronic obstructive pulmonary disease

Summary of findings table ‐ immunostimulant probably leads to lower number of participants requiring antibiotics compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: Bile acid sequestrants vs no intervention

Mean GI symptom scores (during RT) · People with pelvic cancer

It is very uncertain whether summary of findings: Bile acid sequestrants changes mean GI symptom scores (during RT) compared with no intervention (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Silicone earplugs vs no earplugs

All‐cause mortality during hospital stay · preterm or very low birth weight infants

It is very uncertain whether summary of findings table ‐ Silicone earplugs changes all‐cause mortality during hospital stay compared with no earplugs (very low certainty).

1 finding from 1 review