Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

101 questions · 102 findings · 38 reviews · Eyes and Vision

No studies found 20 · 19.6%GRADE not reported 0 · 0%Very low 31 · 30.4%Low 27 · 26.5%Moderate 15 · 14.7%High 9 · 8.8%

Intervention not reported

Progression (increase in maximal keratometry of 1.5 dioptres or more) · people with keratoconus

It is very uncertain whether the intervention changes progression (increase in maximal keratometry of 1.5 dioptres or more) (very low certainty).

1 finding from 1 review

Intraoperative 5‐Fluorouracil vs placebo or control

Failure at 12 months Need for repeat surgery or uncontrolled IOP (usually more than 22 mm Hg) despite additional topical or systemic medications · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) vs photorefractive keratectomy (PRK)

Lost one or more lines of BCVA · patients with myopia

Laser‐assisted in‐situ keratomileusis (LASIK) showed no clear difference in lost one or more lines of BCVA compared with photorefractive keratectomy (PRK) (low certainty).

1 finding from 1 review

Intervention not reported

Contrast threshold loss ‐0.15 log units or more at 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in contrast threshold loss ‐0.15 log units or more at 1 year (moderate certainty).

1 finding from 1 review

Intervention not reported

Reading speed 40 word/minute or more after 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in reading speed 40 word/minute or more after 1 year (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

BCVA: loss of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 3 or more lines (15 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Six or more lines visual acuity lost · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 6 or more lines (30 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to higher gain of 3 or more lines (15 or more letters) compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Eyes within ± 0.5 D of target refraction · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical… showed no clear difference in proportion of eyes within ± 0.5 diopters of target refraction, 12… compared with LASIK with a femtosecond laser (low certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Mean refractive error expressed as mean spherical equivalent post‐treatment. ‐ 12 months · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism
1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Adverse effects: corneal haze · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism

It is very uncertain whether laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical… changes corneal haze, any time point compared with LASIK with a femtosecond laser (very low certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Dry eye, any time point · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical… may leads to higher dry eye, any time point compared with LASIK with a femtosecond laser (low certainty).

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Diffuse lamellar keratitis, any time point · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical… may leads to lower diffuse lamellar keratitis, any time point compared with LASIK with a femtosecond laser (low certainty).

1 finding from 1 review