Cochrane · systematic review · CD010621
Corneal collagen cross‐linking for treating keratoconus
Sykakis, E, Karim, R, Evans, JR, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 1 · 14.3%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with keratoconus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Progression (increase in maximal keratometry of 1.5 dioptres or more) | RR 0.12 [0.01, 2] | 1 study · 19 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Steepness of the cornea (maximal keratometry) (measured using dioptres. A higher dioptre represents steeper cornea and worse outcome) | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Uncorrected visual acuity (UCVA) (measured using logMAR scale. A score of 0 = good vision, higher score is worse vision) | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Corneal thickness at the thinnest part of the cornea (measured in microns) | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Absolute spherical equivalent (measured in dioptres) | no estimate extracted | 1 study · 94 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Quality of life | no estimate extracted | NR | No studies |
Adverse effects | no estimate extracted | 1 study · 3 participants | Ungraded |