Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · preterm infants

Lower showed no clear difference in severe retinopathy of prematurity (≥ stage 3) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Severe intraventricular haemorrhage · preterm infants

Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Necrotising enterocolitis · preterm infants

Lower showed no clear difference in necrotising enterocolitis compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Chronic lung disease · preterm infants

It is very uncertain whether lower changes chronic lung disease (36 weeks' corrected age) compared with higher oxygen concentrations titrated to target oxygen saturations… (very low certainty).

1 finding from 1 review

Low‐frequency electroacupuncture vs physical exercise or no intervention

Restored regular menstrual period · polycystic ovarian syndrome

It is very uncertain whether low‐frequency electroacupuncture changes restored regular menstrual period – low‐frequency electroacupuncture… compared with physical exercise or no intervention (very low certainty).

2 findings from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 300/450 IU vs 150 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in 400/450 IU vs 300 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Anticipated low‐responders: higher vs lower dose of FSH

IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure

Anticipated low responders: higher showed no clear difference in IU vs 450 IU compared with lower dose of FSH (low certainty).

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Lower incisor inclination (lingual tipping and retrusion) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Extraction of lower deciduous canines showed no clear difference in lower incisors to mandible (inclination, degrees) at 1 year compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether extraction of lower deciduous canines changes amount of crowding (lower incisor crowding, change) at 1-2 years compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Extraction of lower deciduous canines led to lower size of the lower jaw (arch length, change) at 1 year compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Death of the baby before discharge: perinatal death · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes death of the baby before discharge: perinatal death: lower dose… compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Recurrence of convulsions · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes recurrence of convulsions: lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Severe morbidity (renal failure): lower dose versus Pritchard regimen · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes severe morbidity (renal failure): lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Upper clear plastic retainer + lower fixed canine-to-canine retainer vs Positioner

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

Upper clear plastic retainer + lower fixed canine-to-canine retainer led to lower stability: Little's Irregularity Index (lower arch) compared with positioner; GRADE not reported.

1 finding from 1 review

Upper clear plastic retainer + lower interproximal reduction (adjunctive) vs Positioner

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

Upper clear plastic retainer + lower interproximal reduction… led to lower stability: Little's Irregularity Index (lower arch) compared with positioner; GRADE not reported.

1 finding from 1 review