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What do systematic reviews say?

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Evidence found and GRADE certainty

1,361 questions · 1,518 findings · 352 reviews

No studies found 73 · 4.8%GRADE not reported 211 · 13.9%Very low 500 · 32.9%Low 411 · 27.1%Moderate 252 · 16.6%High 71 · 4.7%

Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Higher dose vitamin K vs lower dose vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM · preterm infants

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

1 finding from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review