Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,233 findings · 137 reviews

No studies found 190 · 15.4%GRADE not reported 57 · 4.6%Very low 241 · 19.5%Low 323 · 26.2%Moderate 315 · 25.5%High 107 · 8.7%

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes mortality (all‐cause) compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Pneumonia · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes pneumonia compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Hospital admissions · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes hospital admissions (all‐cause) compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Intervention not reported

Residual pleural fluid on chest X‐ray at 8 weeks · adults and adolescents with pleural TB

The intervention may leads to lower residual pleural fluid on chest X‐ray at 8 weeks (low certainty).

1 finding from 1 review

Intervention not reported

Residual pleural fluid on chest X‐ray at 24 weeks · adults and adolescents with pleural TB

The intervention may leads to lower residual pleural fluid on chest X‐ray at 24 weeks (low certainty).

1 finding from 1 review

Intervention not reported

Pleural changes at the end of · adults and adolescents with pleural TB

The intervention may leads to lower pleural changes at the end of (low certainty).

1 finding from 1 review

Intervention not reported

Long‐term functional respiratory impairment (> 6 months) · adults and adolescents with pleural TB
1 finding from 1 review

Intervention not reported

Adverse events leading to treatment discontinuation ( · adults and adolescents with pleural TB

The intervention may leads to higher adverse events leading to treatment discontinuation ( (low certainty).

1 finding from 1 review

Intervention not reported

HIV‐related infections (cryptococcal meningitis) · adults and adolescents with pleural TB

It is very uncertain whether the intervention changes HIV‐related infections (cryptococcal meningitis) (very low certainty).

1 finding from 1 review

Intervention not reported

HIV‐related cancer (Kaposi's sarcoma) · adults and adolescents with pleural TB

It is very uncertain whether the intervention changes HIV‐related cancer (Kaposi's sarcoma) (very low certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among survivors)

CLD at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Death or bronchopulmonary dysplasia at 36 weeks PMA · Neonates with developing BPD

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

2 findings from 1 review

Inhaled steroids vs systemic steroids

Diastolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review