Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,377 questions · 1,433 findings · 149 reviews · Headline outcomes only

No studies found 326 · 22.7%GRADE not reported 87 · 6.1%Very low 440 · 30.7%Low 364 · 25.4%Moderate 190 · 13.3%High 26 · 1.8%

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy (reassurance, retention control training + wakening, parental involvement) · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Intervention not reported

Family relationship Pre‐intervention and post‐intervention assessment Home visits and training session for family members Patient‐caregiver relationships assessed pre‐intervention and immediately post‐intervention. · caregivers of patients with sickle cell disease
1 finding from 1 review

Intervention not reported

Task‐oriented training · people with multiple sclerosis
1 finding from 1 review