Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
75,239 questions in 5,342 reviews
current versionsNo studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table ‐ Kappa‐opioid agonists vs placebo Risk for at least one adverse drug reaction (ADR) per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 1.73 [1.2, 2.48] | 5 studies · 1344 participants | Low |
Summary of findings table ‐ Ondansetron vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 4 studies · 202 participants | Low |
Summary of findings table ‐ Ondansetron vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Quality of life ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Ondansetron vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.54 [0.38, 16.78] | 3 studies · 174 participants | Very low |
Summary of findings table ‐ Montelukast vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 87 participants | Very low |
Summary of findings table ‐ Montelukast vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Montelukast vs placebo Risk for at least one adverse event per participant ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Prurits · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 4 studies · 212 participants | Low |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Quality of life ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Patient satisfaction ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Depression ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Patient satisfaction ‐ not measured · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Fish‐oil/omega‐3 fatty acids vs placebo Adverse events ‐ not measured · chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 76 participants | Low |
Summary of findings table ‐ Zinc sulphate vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Zinc sulphate vs placebo Risk for at least one adverse event per participant · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 160 participants | Ungraded |
Summary of findings table ‐ Cromolyn sodium vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 100 participants | Very low |
Summary of findings table ‐ Cromolyn sodium vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Depression ‐ not reported · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Cromolyn sodium vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 1.28 [0.02, 106.52] | 2 studies · 122 participants | Very low |
Summary of findings table ‐ Topical capsaicin vs placebo Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 112 participants | Low |
Summary of findings table ‐ Topical capsaicin vs placebo Quality of life ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Patient satisfaction ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Depression ‐ not measured · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Topical capsaicin vs placebo Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 3.69 [1.17, 11.67] | 3 studies · 116 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo PruritusScale from: 0 to 10 · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 52 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo Quality of life ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Naltrexone vs placebo Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Naltrexone vs placebo Depression ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ GABA‐analogues vs placebo Risk for at least one adverse event per patient · health problem or population Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.63 [0.76, 9.05] | 1 study · 15 participants | Low |
Summary of findings table ‐ Naltrexone vs placebo Risk for at least one adverse event per patient · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.67 [1.32, 5.39] | 1 study · 40 participants | Low |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Pruritus · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 42 participants | Very low |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Quality of life ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Depression ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Rifampin/rifampicin vs placebo Risk for at least one adverse event per patient · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 0.29 [0.03, 2.51] | 1 study · 39 participants | Very low |
Summary of findings table ‐ Flumecinol vs placebo Pruritus: significant improvement · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | RR 2.32 [0.54, 10.1] | 2 studies · 69 participants | Very low |
Summary of findings table ‐ Flumecinol vs placebo Pruritus · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Summary of findings table ‐ Flumecinol vs placebo Quality of life · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 1 study · 50 participants | Low |
Summary of findings table ‐ Flumecinol vs placebo Patient satisfaction ‐ not measured · patients with cholestatic pruritus (CP) Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Gabapentin vs pregabalin Pruritus · patients with chronic kidney disease (CKD) pruritus Pharmacological interventions for pruritus in adult palliative care patients (2024) · Cochrane | no estimate extracted | 2 studies · 100 participants | Low |