Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,245 questions · 1,274 findings · 321 reviews

No studies found 247 · 19.4%GRADE not reported 195 · 15.3%Very low 372 · 29.2%Low 282 · 22.1%Moderate 141 · 11.1%High 37 · 2.9%

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating warm meals more than twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Drinking sports drinks no more than once per week · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

30 minutes of one-to-one instruction by a dental hygienist covering the relationship between sugar consumption and dental health, plus oral hygiene, fluoride and regular dental visits (a multi-intervention) vs No special instructions (control)

Mean sugar consumption (self-reported, 1 to 5 scale; higher score = more positive behaviour) · Adults newly registered at a group dental practice in a suburban Dutch village, the Netherlands
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Using xylitol products more than 3 times per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

Individually designed, patient-centred preventive programme: dietary… led to higher using xylitol products more than 3 times per day compared with basic prevention offered as standard in public dental clinics; GRADE not reported.

1 finding from 1 review

Intervention not reported

A significant 14% reduction in mean speeds compared to control sites. The proportion of vehicles exceeding the speed limit by more than 10mph decreased by 82%.
1 finding from 1 review

Intervention not reported

Speed outcomes measured: Mean speed, 85th percentile speed, percentage of vehicles over the speed limit and percentage exceeding the speed limit by more than 15mph. Speed results across all new camera sites included a 2.3mph reduction (6% reductio...
1 finding from 1 review

Intervention not reported

A 30% reduction in vehicles exceeding the speed limit, and a 43% reduction in vehicles exceeding the speed limit by more than 15 mph. Time over distance cameras were shown to be particularly effective (around 100% reduction) at reducing speeds exc...

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Weight: Gain‐more than or equal to 7% from baseline · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

The intervention showed no clear difference in weight: Gain‐more than or equal to 7% from baseline (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs haloperidol

Global outcome: Number of additional injections ‐ 5 or more · patients with psychosis‐induced aggression or agitation

It is very uncertain whether CHLORPROMAZINE changes global outcome: Number of additional injections ‐ 5 or more compared with HALOPERIDOL (very low certainty).

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Tenderness on palpation of three or more masticatory muscles · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in tenderness on palpation of three or more masticatory muscles compared with placebo; GRADE not reported.

1 finding from 1 review

Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo

Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels

Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.

1 finding from 1 review

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in adults ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in children and adolescents ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Intervention not reported

Contrast threshold loss ‐0.15 log units or more at 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in contrast threshold loss ‐0.15 log units or more at 1 year (moderate certainty).

1 finding from 1 review

Intervention not reported

Reading speed 40 word/minute or more after 1 year · patients with choroidal neovascularisation secondary to age‐related macular degeneration

The intervention showed no clear difference in reading speed 40 word/minute or more after 1 year (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

BCVA: loss of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 3 or more lines (15 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Six or more lines visual acuity lost · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to lower loss of 6 or more lines (30 or more letters) visual acuity ETDRS chart compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review

Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Photodynamic therapy with verteporfin leads to higher gain of 3 or more lines (15 or more letters) compared with photodynamic therapy with 5% dextrose (high certainty).

1 finding from 1 review