Question · asked by 1 review
Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs placebo: Increase in volume of more than 10% compared to the pretreatment measurement
- Population
- Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH) levels
- Intervention
- Calcitonin (salmon calcitonin nasal spray 200 IU/day)
- Comparison
- placebo
- Outcome
- Increase in volume of more than 10% compared to the pretreatment measurement
Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Calcitonin (salmon calcitonin nasal spray 200 IU/day) vs Placebo Increase in volume of more than 10% compared to the pretreatment measurement · Patients with histologically confirmed CGCG in one or both jaws and normal serum calcium and parathyroid hormone (PTH)… · 3 months Calcitonin (salmon calcitonin nasal spray 200 IU/day) showed no clear difference in increase in volume of more than 10% compared to the pretreatment… compared with placebo; GRADE not reported. Interventions for central giant cell granuloma (CGCG) of the jaws (2009) · Cochrane All outcomes | RR 3.0 [0.40, 22.30] | 1 study · 14 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for central giant cell granuloma (CGCG) of the jaws 2009 · Cochrane All outcomes | 2009-07 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.