Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,181 questions · 1,197 findings · 144 reviews

No studies found 196 · 16.4%GRADE not reported 213 · 17.8%Very low 274 · 22.9%Low 296 · 24.7%Moderate 171 · 14.3%High 47 · 3.9%

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after counselling (counselling) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions showed no clear difference in tobacco abstinence after counselling (counselling) compared with placebo or usual care (low certainty).

1 finding from 1 review

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after pharmacotherapy (pharmacotherapy) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions may leads to higher tobacco abstinence after pharmacotherapy (pharmacotherapy) compared with placebo or usual care (low certainty).

1 finding from 1 review

Tobacco cessation interventions vs placebo or usual care

Tobacco abstinence after combined counselling and pharmacotherapy (combined) · people in treatment for or recovery from alcohol or other drug dependency

Tobacco cessation interventions may leads to higher tobacco abstinence after combined counselling and pharmacotherapy… compared with placebo or usual care (low certainty).

1 finding from 1 review

Intervention not reported

Failure of sustained virological response Absence of clearance of HCV RNA from the blood 6 months after treatment · patients with chronic hepatitis C.

The intervention may leads to higher failure of sustained virological response Absence of clearance of… (low certainty).

1 finding from 1 review

Intervention not reported

Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment · patients with chronic hepatitis C.

The intervention may leads to higher failure of end of treatment virological response Absence of… (low certainty).

1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of treatment · patients with chronic hepatitis C.

It is very uncertain whether the intervention changes failure of normalisation of ALT at end of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Achieved recovery according to predetermined criteria (no longer meeting criteria for depression on K‐SADS or meeting a priori criteria for response on a depression checklist, assessed between 4 and 10 weeks of onset of treatment) · children and adolescents with depression

The intervention showed no clear difference in achieved recovery according to predetermined criteria (no longer… (low certainty).

1 finding from 1 review

Intervention not reported

Change in clinical global assessment scale scores (CGI scale or CGAS rated between 4 and 10 weeks of onset of treatment) · children and adolescents with depression
1 finding from 1 review

Intervention not reported

Number of withdrawals (occurring between 4 and 10 weeks of onset of treatment) · children and adolescents with depression

The intervention showed no clear difference in number of withdrawals (occurring between 4 and 10 weeks of onset of… (low certainty).

1 finding from 1 review

Oral NSAIDs vs glucocorticoid injection

Treatment success Fair, good or excellent effectiveness · Adults with lateral elbow pain

It is very uncertain whether oral NSAIDs changes treatment success Fair, good or excellent effectiveness compared with glucocorticoid injection (very low certainty).

1 finding from 1 review