Cochrane · systematic review · CD011132
Aminoadamantanes versus other antiviral drugs for chronic hepatitis C
Lamers, MH, Broekman, M, Drenth, JPH, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: patients with chronic hepatitis C.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality or liver‐related morbidity | RR 0.98 [0, 248.89] | 4 studies · 427 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events | RR 0.56 [0.27, 1.16] | 4 studies · 427 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Failure of sustained virological response Absence of clearance of HCV RNA from the blood 6 months after treatment | RR 1.14 [1.07, 1.22] | 4 studies · 427 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment | RR 1.2 [1.05, 1.36] | 3 studies · 309 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Failure of normalisation of ALT at end of treatment | RR 2.02 [1.07, 3.82] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Failure of normalisation of ALT at end of | RR 1.31 [1.05, 1.63] | 2 studies · 92 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |