Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,181 questions · 1,197 findings · 144 reviews

No studies found 196 · 16.4%GRADE not reported 213 · 17.8%Very low 274 · 22.9%Low 296 · 24.7%Moderate 171 · 14.3%High 47 · 3.9%

Oral drug treatment vs topical treatments

Primary outcome 2: Clinical recurrence at 6 months · non‐pregnant women with a diagnosis of recurrent vulvovaginal candidiasis

It is very uncertain whether oral drug treatment changes primary outcome 2: Clinical recurrence at 6 months compared with topical drug treatment (very low certainty).

1 finding from 1 review

Short‐duration antiepileptic drug treatment vs long‐duration antiepileptic drug treatment

Seizure control Seizure recurrence · people with neurocysticercosis

Short‐duration antiepileptic drug treatment showed no clear difference in seizure control(seizure recurrence) compared with long‐duration antiepileptic drug treatment (low certainty).

1 finding from 1 review

Six to 12 months AED treatment vs 24 months AED treatment

Seizure control Seizure recurrence · people with neurocysticercosis

It is very uncertain whether six‐ to 12‐month antiepileptic drug treatment changes seizure control (seizure recurrence) compared with 24‐month antiepileptic drug treatment (very low certainty).

1 finding from 1 review

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Acceptability of treatment ‐ leaving the study early · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower leaving the study early: due to any reason (acceptability of… compared with placebo/no treatment (high certainty).

1 finding from 1 review

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Discontinuation of medication due to adverse events

It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes withdrawls or drug discontinuation due to adverse events during 24… compared with placebo? (very low certainty).

1 finding from 1 review