Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

358 questions · 403 findings · 68 reviews

No studies found 43 · 10.7%GRADE not reported 121 · 30%Very low 128 · 31.8%Low 66 · 16.4%Moderate 33 · 8.2%High 12 · 3%

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Restoration survival · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride-containing dental care products (mainly fluoride toothpaste; one study also included fluoride varnish) vs Dietary fluoride sources (drinking water, beverages, food)

Contribution of dental care products to total daily fluoride intake (TDFI) · Humans using fluoride-containing dental care products; 28 included studies, mostly young children, only two studies in adults (aged…

Fluoride-containing dental care products (mainly toothpaste) contributed on average 38% (SD 27%) of total daily fluoride intake, regardless of tap-water fluoride level or age (ungraded; descriptive synthesis, no meta-analysis).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in continuous abstinence from cocaine (number of participants who had… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

At 18 months, laser preparation alone did not differ significantly from acid-etching for sealant retention (OR 0.82, 95% CI 0.23 to 2.85; ungraded, single study, high risk of bias).

6 findings from 1 review
Show 3 more findings

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Calculus · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in calculus at 7 months (Volpe-Manhold Calculus Index, mean height of… compared with fluoride toothpaste without triclosan; GRADE not reported.

2 findings from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Participant-centred outcomes (quality of life; satisfaction with product) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

The review found no eligible studies for this question.

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Plaque · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower plaque at 6 to 7 months (Quigley-Hein Plaque Index, 0 to 5 scale) compared with fluoride toothpaste without triclosan (moderate certainty).

3 findings from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Dental caries: prevalence of root caries · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower root caries at 36 months (Katz Root Caries Index) compared with fluoride toothpaste without triclosan (moderate certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Gingival bleeding (various bleeding indices) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower gingival bleeding at 6 to 7 months (Gingivitis Severity Index,… compared with fluoride toothpaste without triclosan (moderate certainty).

2 findings from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Gingivitis · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste probably leads to lower gingivitis at 6 to 9 months (Loe-Silness Gingival Index, 0 to 3 scale) compared with fluoride toothpaste without triclosan (moderate certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Coronal caries increment · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in coronal caries increment at 30 to 36 months (decayed filled teeth,… compared with fluoride toothpaste without triclosan (high certainty).

2 findings from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Periodontitis (clinical attachment loss) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in periodontitis at 36 months (attachment loss > 0 mm) compared with fluoride toothpaste without triclosan (low certainty).

1 finding from 1 review

Tailoring asthma treatment using FeNO vs clinical symptoms

Asthma exacerbations · children with asthma

It is very uncertain whether tailoring asthma treatment using fractional exhaled nitric oxide changes number of asthma exacerbations per 52 weeks (exacerbation rate) compared with clinical symptoms (very low certainty).

1 finding from 1 review

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Caries presence in primary teeth · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

Breastfeeding promotion and support (e.g. individually tailored… showed no clear difference in caries presence in primary teeth compared with standard care (low certainty).

1 finding from 1 review