Cochrane · intervention · CD010514
Triclosan/copolymer containing toothpastes for oral health
Riley, P, Lamont, T · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Full textEvery question was extracted from the full review (methods and results), not only its Summary of Findings table.
Questions
14
current version
GRADE rated
9
No studies
1
Included studies
30
as reported
No studies 1 · 7.1%Ungraded 4 · 28.6%Very low 0 · 0%Low 2 · 14.3%Moderate 5 · 35.7%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and adults (aged 16 years or less classified as children, over 16 as adults); excludes participants with periodontitis at baseline, those selected for a pre-existing health condition, and studies where the majority wear orthodontic appliances | Adults and children; 14,835 participants analysed (per-study range 54 to 3462); 2 studies in children (mean age 12.7, range 11 to 13); 28 studies in adults (age 18 to 81); mostly female; 1 study in pregnant women (n=14835) |
| Intervention | Any fluoride toothpaste containing a triclosan/copolymer combination | Triclosan/copolymer/fluoride toothpaste (0.3% triclosan, 2% copolymer; sodium fluoride, mostly 1100 ppm) (n=14835) |
| Comparison | Any fluoride toothpaste without triclosan | Fluoride toothpaste without triclosan (mostly 0.243% sodium fluoride/1100 ppm; 2 studies used placebo) (n=14835) |
| Outcomes | Primary: Plaque levels (any scale); Gingival health (any scale). Secondary: Incidence of periodontitis; Caries (new incidence; caries increment, change in DMFS/dmfs index); Calculus (any scale); Adverse effects; Participant-centred outcomes (quality of life; satisfaction) | Plaque, Quigley-Hein Plaque Index (n=2675); Plaque Severity Index (n=1850); Loe-Silness Plaque Index (n=148); Gingivitis, Loe-Silness Gingival Index (n=2743); Gingivitis Severity Index/bleeding (n=1998); number of bleeding sites (n=329); Periodontitis, attachment loss (n=480); Coronal caries DFS (n=9692); Coronal caries DFT (n=6300); Root caries, Katz Root Caries Index (n=1357); Calculus, Volpe-Manhold total (n=415); Volpe-Manhold height (n=78); Adverse effects, tooth staining Meckel Stain Score (n=325) |
| Study designs | Randomised controlled trials of parallel or cross-over design, irrespective of language or publication status; cross-over studies require a washout of at least 3 weeks and duration of at least 1 year; minimum 6-month duration; cluster-RCTs eligible; split-mouth designs excluded | Randomised controlled trials; all 30 of parallel-group design (20 two-arm, 7 three-arm, 3 four-arm); all single-centre (n=30) |
| Timing | Outcome data at 6 months of follow-up or longer | 6 to 7 months (plaque, calculus); 6 to 9 months (gingivitis); 36 months (periodontitis, root caries); 24 to 36 months (coronal caries DFS); 30 to 36 months (coronal caries DFT) |
Search date: 2013-08. Databases: Cochrane Oral Health's Trials Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE via OVID; Embase via OVID; US National Institutes of Health Trials Register
Questions and results
Show all 2 versionsTriclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan
Population: Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults, with children in 2 studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Calculus at 7 months (Volpe-Manhold Calculus Index, mean height of calculus in mm) 7 months | MD -0.04 [-0.21, 0.13] | 1 study · 78 participants | Ungraded |
Participant-centred outcomes (quality of life; satisfaction with product) | No studies reported any participant-centred outcomes. | 0 studies | No studies |
Plaque at 6 to 7 months (Quigley-Hein Plaque Index, 0 to 5 scale) 6 to 7 months | MD -0.47 [-0.60, -0.34] | 20 studies · 2675 participants | Moderate Downgraded: inconsistency |
Plaque severity at 6 to 7 months (Plaque Severity Index, proportion of surfaces scoring > 3 on the Quigley-Hein Plaque Index) 6 to 7 months | MD -0.15 [-0.20, -0.10] | 13 studies · 1850 participants | Moderate Downgraded: inconsistency |
Calculus at 6 months (Volpe-Manhold Calculus Index in mm, mean total calculus per participant) 6 months | MD -2.12 [-3.39, -0.84] | 2 studies · 415 participants | Low Downgraded: risk of bias, inconsistency |
Root caries at 36 months (Katz Root Caries Index) 36 months | MD -0.31 [-0.39, -0.23] | 1 study · 1357 participants | Moderate Downgraded: risk of bias |
Gingivitis at 6 to 9 months (Loe-Silness Gingival Index, 0 to 3 scale) 6 to 9 months | MD -0.27 [-0.33, -0.21] | 20 studies · 2743 participants | Moderate Downgraded: inconsistency |
Coronal caries increment at 30 to 36 months (decayed filled teeth, DFT) 30 to 36 months | MD -0.06 [-0.14, 0.02] | 3 studies · 6300 participants | High |
Adverse effects (tooth staining, Meckel Stain Score, 6 months) 6 months | MD -0.15 [-0.60, 0.30] | 1 study · 325 participants | Ungraded |
Gingival bleeding at 6 to 7 months (Gingivitis Severity Index, proportion of sites bleeding, i.e. 2 or 3 on the Loe-Silness Gingival Index) 6 to 7 months | MD -0.13 [-0.17, -0.08] | 15 studies · 1998 participants | Moderate Downgraded: inconsistency |
Gingival bleeding at 6 months (number of sites bleeding on probing or spontaneously) 6 months | MD 0.14 [-1.11, 1.39] | 1 study · 329 participants | Ungraded |
Coronal caries increment at 24 to 36 months (decayed filled surfaces, DFS) 24 to 36 months | MD -0.16 [-0.31, -0.02] | 4 studies · 9692 participants | High |
Plaque at 6 to 7 months (Loe-Silness Plaque Index) 6 to 7 months | MD -0.05 [-0.10, -0.01] | 2 studies · 148 participants | Ungraded |
Periodontitis at 36 months (attachment loss > 0 mm) 36 months | RR 0.92 [0.67, 1.27] 249 per 1000 vs 229 per 1000 | 1 study · 480 participants | Low Downgraded: risk of bias, imprecision |