Same question across reviews · CL0155
intervention :: Fluoride toothpaste/dentifrice -> Microbiological/plaque
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
3
Questions
9
current versions
GRADE rated
3
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postbiotic toothpaste vs Fluoride toothpaste Salivary Streptococcus mutans count · Children aged 6 to 12 years · 4 weeks Postbiotics and Dental Caries: A Systematic Review. (2025) | no estimate extracted | 1 study | Ungraded |
Postbiotic toothpaste vs Fluoride toothpaste Increased salivary IgA · Children aged 6-12 years · Daily for 14 days to 4 weeks Postbiotics and Dental Caries: A Systematic Review. (2025) | Postbiotic toothpaste significantly increased salivary IgA versus fluoride toothpaste (Basir 2022); the review also cites Lin 2022 for postbiotic immune modulation/IgA; no pooled estimate. | 1 study | Ungraded |
Postbiotic toothpaste vs Fluoride toothpaste Increased salivary pH · Children aged 6-12 years · 4 weeks Postbiotics and Dental Caries: A Systematic Review. (2025) | Postbiotic toothpaste significantly increased salivary pH versus fluoride toothpaste in children (Basir 2022); postbiotics are also proposed to buffer acidic pH; no pooled estimate. | 1 study | Ungraded |
Postbiotic products (postbiotic toothpaste; heat-killed/postbiotic oral lozenges; inactivated-bacteria tablets) vs Placebo, fluoride toothpaste, or standard post-filling care (varies by trial) Reduced salivary S. mutans counts · Humans at risk of dental caries (children aged 6-12 years; adults with dental caries) · Daily for 14 days to 4 weeks Postbiotics and Dental Caries: A Systematic Review. (2025) | Three RCTs reported reduced salivary S. mutans counts after postbiotic intervention; the reduction was statistically significant in Lin 2022 but non-significant in Basir 2022; no pooled estimate. | 3 studies | Ungraded |
Postbiotic toothpaste vs Fluoride toothpaste Salivary immunoglobulin A and pH · Children aged 6 to 12 years · 4 weeks Postbiotics and Dental Caries: A Systematic Review. (2025) | no estimate extracted | 1 study | Ungraded |
1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily Visible plaque index (mean change from baseline) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 1.5 years Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | MD -0.09 [-0.18, 0] | 1 study · 97 participants | Very low |
Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan Plaque at 6 to 7 months (Quigley-Hein Plaque Index, 0 to 5 scale) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in… · 6 to 7 months Triclosan/copolymer containing toothpastes for oral health (2013) · Cochrane | MD -0.47 [-0.60, -0.34] | 20 studies · 2675 participants | Moderate |
Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan Plaque severity at 6 to 7 months (Plaque Severity Index, proportion of surfaces scoring > 3 on the Quigley-Hein Plaque Index) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in… · 6 to 7 months Triclosan/copolymer containing toothpastes for oral health (2013) · Cochrane | MD -0.15 [-0.20, -0.10] | 13 studies · 1850 participants | Moderate |
Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan Plaque at 6 to 7 months (Loe-Silness Plaque Index) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in… · 6 to 7 months Triclosan/copolymer containing toothpastes for oral health (2013) · Cochrane | MD -0.05 [-0.10, -0.01] | 2 studies · 148 participants | Ungraded |