Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

111 questions · 116 findings · 35 reviews · Neonatal

No studies found 17 · 14.7%GRADE not reported 0 · 0%Very low 32 · 27.6%Low 29 · 25%Moderate 26 · 22.4%High 12 · 10.3%

Cerebral NIRS oximetry vs no cerebral NIRS oximetry

Oxygen requirement at 36 weeks' postmenstrual age · patients with preventing morbidity and mortality in very preterm infants

It is very uncertain whether cerebral NIRS oximetry changes chronic lung disease (oxygen supplementation at 36 weeks'… compared with no cerebral NIRS oximetry (very low certainty).

1 finding from 1 review

Vitamin A vs no supplementation

Chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in chronic lung disease (oxygen use at 28 days in survivors) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A vs no supplementation

Death or chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A probably leads to lower death or chronic lung disease (oxygen use at 28 days) compared with no supplementation (moderate certainty).

2 findings from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Any oxygen desaturation occurring 12‐24 hours following completion of the operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in any oxygen desaturation occurring 12‐24 hours following completion… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Death or oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in death or oxygen requirement at 36 weeks' postmenstrual age compared with modified bovine minced lung surfactant extract (high certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract

Oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for treatment of RDS

Bovine lung lavage surfactant extract showed no clear difference in oxygen requirement at 36 weeks' postmenstrual age compared with porcine minced lung surfactant extract (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs modified bovine minced lung surfactant extract

Oxygen requirement at 36 weeks' postmenstrual age · Preterm infants for prevention of RDS

Bovine lung lavage surfactant extract showed no clear difference in oxygen requirement at 36 weeks' postmenstrual age compared with modified bovine minced lung surfactant extract (moderate certainty).

1 finding from 1 review