Cochrane · systematic review · CD006183
Antibiotics for neonates born through meconium‐stained amniotic fluid
Kelly, LE, Shivananda, S, Murthy, P, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 12 · 92.3%Moderate 1 · 7.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics compared with control (no antibiotics) in symptomatic neonates born through meconium‐stained amniotic fluid
Population: symptomatic neonates born through meconium‐stained amniotic fluid
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of confirmed sepsis in first 28 days Antibiotics vs control (no antibiotics) | no estimate extracted | 3 studies · 445 participants | Low |
Mortality (before discharge) Antibiotics vs control (no antibiotics) | RR 1.69 [0.23, 12.53] | 3 studies · 445 participants | Low |
Duration of oxygen therapy, days Antibiotics vs control (no antibiotics) | no estimate extracted | 2 studies · 405 participants | Low |
Duration of hospital stay, days Antibiotics vs control (no antibiotics) | no estimate extracted | 1 study · 146 participants | Moderate |
Incidence of mechanical ventilation Antibiotics vs control (no antibiotics) | RR 1.18 [0.52, 2.67] | 3 studies · 445 participants | Low |
Incidence of respiratory failure Antibiotics vs control (no antibiotics) | RR 1.2 [0.51, 2.83] | 2 studies · 405 participants | Low |
Antibiotics compared with control (no antibiotics) in asymptomatic neonates born through meconium‐stained amniotic fluid
Population: asymptomatic neonates born through meconium‐stained amniotic fluid
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of confirmed sepsis in first 28 days Antibiotics vs control (no antibiotics) | no estimate extracted | 1 study · 250 participants | Low |
Mortality (before discharge) Antibiotics vs control (no antibiotics) | RR 1.07 [0.22, 5.18] | 1 study · 250 participants | Low |
Duration of oxygen therapy, days Antibiotics vs control (no antibiotics) | no estimate extracted | 1 study · 250 participants | Low |
Incidence of suspected sepsis Antibiotics vs control (no antibiotics) | no estimate extracted | 1 study · 250 participants | Low |
Incidence of mechanical ventilation Antibiotics vs control (no antibiotics) | RR 2.13 [0.55, 8.34] | 1 study · 250 participants | Low |
Duration of respiratory distress, hours Antibiotics vs control (no antibiotics) | no estimate extracted | 1 study · 250 participants | Low |
Incidence of MAS Antibiotics vs control (no antibiotics) | RR 1.17 [0.67, 2.04] | 1 study · 250 participants | Low |