Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

153 questions · 155 findings · 33 reviews · Gut

No studies found 40 · 25.8%GRADE not reported 2 · 1.3%Very low 31 · 20%Low 42 · 27.1%Moderate 34 · 21.9%High 6 · 3.9%

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).

1 finding from 1 review

Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes endoscopic recurrence (at week 102) compared with initiation of prophylactic therapy immediately after surgery (very low certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain endoscopic remission · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain endoscopic remission compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain clinical or endoscopic response with prior TNF‐α antagonist exposure · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain clinical or endoscopic response with prior TNF‐α… compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs active comparators

Failure to maintain endoscopic remission · People with quiescent Crohn's disease (ileocolic resection)

It is very uncertain whether adalimumab changes failure to maintain endoscopic remission compared with active comparator (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Endoscopic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes endoscopic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic response · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review