Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

199 questions · 351 findings · 38 reviews

No studies found 0 · 0%GRADE not reported 338 · 96.3%Very low 4 · 1.1%Low 8 · 2.3%Moderate 1 · 0.3%High 0 · 0%

Secondary (passive/secondhand) smoking exposure during childhood vs No secondary smoking exposure

Early childhood caries (ECC) - incidence/risk · Preschool children aged <=71 months (caries outcome assessed at 3-6 years)

Children exposed to secondary smoking from infancy have a higher incidence of early childhood caries by age 3 (RR 1.45; low certainty).

1 finding from 1 review

Nocturnal breastfeeding vs No nocturnal breastfeeding

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding one study, nocturnal breastfeeding was associated with higher ECC risk (RR 3.05, 95% CI 2.40 to 3.87; I²=33%).

2 findings from 1 review

Cesarean section delivery vs Vaginal delivery

Early childhood caries (ECC) · Children aged <6 years

No significant association between cesarean vs vaginal delivery and ECC among America/Canada/Brazil studies (OR 1.11, 95% CI 0.70-1.76).

17 findings from 1 review
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Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years)

Mean dmft was lowest (1.62 teeth) in low-inequality countries by Gini index.

16 findings from 1 review
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Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Early childhood caries (ECC) · Children younger than 71 months (under 6 years)

Pooled ECC prevalence in Europe was 36% (95% CI 25-47).

16 findings from 1 review
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Breastfeeding <24 months vs Breastfeeding for ≥24 months

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding Peres et al. (2017), breastfeeding for less than 24 months was associated with fewer caries (RR 0.49, 95% CI 0.39 to 0.62; I²=6%).

2 findings from 1 review

Breastfeeding vs No breastfeeding

Early childhood caries (ECC) · Preschool children (<6 years)

After excluding five studies, breastfeeding was associated with lower ECC risk in cohort studies (RR 0.82, 95% CI 0.71 to 0.95; I²=0%).

3 findings from 1 review

Breastfeeding <12 months vs Breastfeeding for ≥12 months

Early childhood caries (ECC) · Preschool children (<6 years)

Breastfeeding for <12 vs ≥12 months was associated with significantly fewer caries (RR 0.65, 95% CI 0.50-0.86), indicating breastfeeding beyond 12 months increases ECC risk (substantial heterogeneity; ungraded).

2 findings from 1 review