Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
MTA and TotalFill BC had comparable pulpotomy success (ungraded).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America
In North America, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -13.28 nmol/l; ungraded).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at age 8-10 (vs after 10) increases odds of space closure (OR 3.32; low certainty).
1 finding from 1 review
Dental caries in children · Children (approx. 4-18 years)
Waist circumference was not significantly associated with childhood dental caries (pooled OR 1.08, 95% CI 0.90 to 1.30; I2=47.7%); ungraded.
1 finding from 1 review
Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment
Negative predictive value was reported in 10 studies and ranged widely across studies (about 31% to 99.5%); no pooled estimate and certainty not graded.
1 finding from 1 review
Intervention not reported
Decayed surfaces (DS)
The intervention led to higher decayed surfaces (DS); GRADE not reported.
1 finding from 1 review
Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
Obesity may make little or no difference to untreated dental caries (low certainty).
1 finding from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Serum 25(OH)D <50 nmol/l (vs 50–75 nmol/l) was associated with higher odds of ECC (OR 1.47; ungraded).
1 finding from 1 review
Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
Overweight may make little or no difference to untreated dental caries (low certainty).
1 finding from 1 review
Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second molar was rotated in about 77% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)
Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).
1 finding from 1 review
Streptococcus mutans count · Children and/or adolescents (<18 years) without background systemic disease
Probiotics probably reduce Streptococcus mutans count versus control (MD -0.40 CFU/mL, 95%CI -0.57 to -0.24; moderate certainty).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 3.81; low certainty).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found space closure more likely with crowding than spacing (OR 5.9; single study; not GRADE-rated).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Children with severe ECC had significantly lower serum 25(OH)D than caries-free children (WMD -18.64 nmol/l; ungraded).
1 finding from 1 review
Dental caries prevalence · Institutionalized orphan children (roughly 3 to 18 years)
Institutionalized orphan children may be at higher risk of dental caries than parented children (pooled RR 1.19), but the estimate is imprecise and not statistically significant (very low certainty).
1 finding from 1 review
Gingival bleeding (various bleeding indices) · Children and/or adolescents (<18 years) without background systemic disease
Only one trial (Borrell 2021) reported the bleeding index, showing slightly more bleeding with probiotics (MD 0.10, 95%CI 0.02 to 0.18); not pooled or GRADE-rated.
1 finding from 1 review
TNF-α level · Children and young adults (3-25 years)
Salivary TNF-α levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 14.81 pg/mL, 95% CI 4.76 to 24.86; 7 studies); ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Preschool children ≤6 years, North America
In North America, 25(OH)D 50–75 nmol/l (vs ≥75) was associated with higher odds of ECC (OR 2.09; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
MTA and calcium-enriched mixture had comparable pulpotomy success (ungraded).
1 finding from 1 review