Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Diode laser, near infrared (700 nm to 850 nm) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Diode laser, near infrared (700 nm to 850 nm) showed no clear difference in changes in intensity of pain (VAS 0 to 10) tested through tactile… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

2 findings from 1 review

Er:YAG laser (erbium-doped:yttrium-aluminum-garnet) vs Placebo (placebo laser or placebo agent) or no treatment

Outcome not reported · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

The review found no eligible studies for this question.

1 finding from 1 review
  • Laser therapy for dentinal hypersensitivity 2021 · Cochrane All outcomes
    We did not find any eligible study to evaluate erbium:yttrium-aluminum-garnet (Er:YAG) or carbon dioxide (CO2) laser compared with placebo/no treatment.
    0 studies
    No studies found

Diode laser, visible red (630 nm to 700 nm) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Diode laser, visible red (630 nm to 700 nm) led to lower changes in intensity of pain (VAS 0 to 10) tested through air blast… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

3 findings from 1 review

CO2 laser (carbon dioxide) vs Placebo (placebo laser or placebo agent) or no treatment

Outcome not reported · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

The review found no eligible studies for this question.

1 finding from 1 review
  • Laser therapy for dentinal hypersensitivity 2021 · Cochrane All outcomes
    We did not find any eligible study to evaluate erbium:yttrium-aluminum-garnet (Er:YAG) or carbon dioxide (CO2) laser compared with placebo/no treatment.
    0 studies
    No studies found

Intervention not reported

Self‐controlled case series ‐ MMR vaccine ‐ age from 9 to 23 months · children 9 months to 15 years old

The intervention probably leads to higher self‐controlled case series ‐ MMR vaccine ‐ age from 9 to 23 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Cohort study (rate ratio) ‐ all ages · children 9 months to 15 years old

The intervention showed no clear difference in cohort study (rate ratio) ‐ all ages (low certainty).

1 finding from 1 review

Intervention not reported

Cohort studies (risk ratio) ‐ all ages · children 9 months to 15 years old

The intervention showed no clear difference in cohort studies (risk ratio) ‐ all ages (low certainty).

1 finding from 1 review

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) showed no clear difference in changes in intensity of pain (VAS 0 to 10) tested through tactile… compared with placebo (placebo laser or placebo agent) or no treatment; GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Intermediate restorative material (IRM)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

Mineral trioxide aggregate (MTA) showed no clear difference in success rate at 2 years compared with intermediate restorative material (IRM); GRADE not reported.

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: disengagement from services (assessed by proportion disengaged, as defined by the study, at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) probably leads to lower service use: disengagement from services (assessed by proportion… compared with treatment (moderate certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Mental state: 1b.Average end point score on various outcomes‐PANSS (medium‐term) ‐ Medium term ‐ PANSS general psychopathology end point score (low = favourable) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
1 finding from 1 review

Conventional occlusion vs atropine penalization

Stereo acuity (different measures and time points reported in the included studies) Assessed at different time points (17 weeks, 6 months, 2 years, or at cessation of treatment) and using different measures (TNO stereo test, Titmus fly test, Rando... · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review