Cochrane · systematic review · CD013682
Whole‐cell pertussis vaccine in early infancy for the prevention of allergy in children
Perez Chacon, G, Ramsay, J, Brennan-Jones, CG, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Tobacco AddictionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 33.3%Very low 2 · 33.3%Low 1 · 16.7%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Efficacy and safety of a first dose of whole‐cell pertussis vaccine compared to a first dose of acellular pertussis vaccine for the prevention of atopic diseases in children
Population: infants younger than six months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cumulative incidence of atopic disease at 2.5 years old Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | no estimate extracted | 1 study · 497 participants | Very low Downgraded: indirectness |
Diagnosis of IgE‐mediated food allergy Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | no estimate extracted | 0 participants | Ungraded |
Diagnosis of asthma Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | no estimate extracted | 1 study · 497 participants | Very low Downgraded: imprecision, indirectness |
Diagnosis of anaphylaxis (not vaccine associated) Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | no estimate extracted | 0 studies · 0 participants | Ungraded |
All‐cause serious adverse events Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | RR 0.94 [0.78, 1.15] | 15 studies · 38072 participants | Moderate Downgraded: imprecision, indirectness |
Diagnosis of encephalopathy Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine | no estimate extracted | 7 studies · 115271 participants | Low Downgraded: imprecision, indirectness |