Findings

What do systematic reviews say?

3,971 questions · 9,849 findings · 853 reviews

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No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
RR 1.01 [0.91, 1.13]
1 study · 882 participants
Low

Percutaneous patellar osteosynthesis vs open surgery

Cosmetic appearance · adults with fractures of the patella

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating fractures of the patella in adults 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Propionyl‐L‐carnitine vs placebo

Absolute claudication distance (MWD + PWT) (in meters) · intermittent claudication

1 finding from 1 review

Propionyl‐L‐carnitine for intermittent claudication 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1121 participants
Moderate

Propionyl‐L‐carnitine vs placebo

Initial claudication distance (PFWD + COT) (in meters) · intermittent claudication

1 finding from 1 review

Propionyl‐L‐carnitine for intermittent claudication 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1151 participants
Moderate

Propionyl‐L‐carnitine vs L‐carnitine

Absolute claudication distance (in meters) · intermittent claudication

1 finding from 1 review

Propionyl‐L‐carnitine for intermittent claudication 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Propionyl‐L‐carnitine vs L‐carnitine

Initial claudication distance (in meters) · intermittent claudication

1 finding from 1 review

Propionyl‐L‐carnitine for intermittent claudication 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Fourteen‐weeks vs 7‐weeks multimodal exercise training

Maximal and functional exercise capacity · adult lung transplant recipients

1 finding from 1 review

Exercise training for adult lung transplant recipients 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Very low

Resistance training vs another form of resistance (anaerobic) exercise training

Maximal and functional exercise capacity · adult lung transplant recipients

1 finding from 1 review

Exercise training for adult lung transplant recipients 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 214 participants
Very low

Sharp‐edged intraocular lens (IOL) vs round‐edged IOL

Posterior capsule opacification score at one year As measured by AQUA score, Evaluation of PCO (EPCO) score and other methods of quantifying PCO · patients undergoing cataract surgery

1 finding from 1 review

Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 10 participants
Moderate

Pharmacological interventions vs pharmacological intervention

Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility

It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
OR 7.22 [0.72, 73]
1 study · 28 participants
Very low

Pharmacological interventions vs pharmacological intervention

Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
OR 5.2 [2.59, 10.4]
1 study · 28 participants
Very low

Pharmacological interventions vs pharmacological intervention

MiscarriageMet + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes miscarriageMet + CC + L‐carnitine vs Met + CC + placebo compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
OR 3.58 [0.73, 17.6]
1 study · 274 participants
Very low

Pharmacological interventions vs pharmacological intervention

Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin · obese women with subfertility

1 finding from 1 review

Pharmacological and non‐pharmacological strategies for obese women with subfertility 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Very low

Bisphosphonate treatment (oral or intravenous) vs placebo or no treatment

Change in volumetric BMD of distal radius or tibia · children under the age of 18 with cerebral palsy (GMFCS levels III to V)

1 finding from 1 review

Bisphosphonate use in children with cerebral palsy 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Topical mydriatics vs intracameral mydriatics

Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) · patients undergoing cataract surgery

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 757 participants
Low

Topical mydriatics vs depot delivery systems

Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) · patients undergoing cataract surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical mydriatics vs depot delivery systems

Mean pupillary diameter—at the beginning of cataract surgery (mm) · patients undergoing cataract surgery

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 324 participants
Low

Topical mydriatics vs depot delivery systems

Mean pupillary diameter—at the end of cataract surgery (mm) · patients undergoing cataract surgery

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 210 participants
Very low

Intracameral mydriatics vs depot delivery systems

Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) · patients undergoing cataract surgery

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical mydriatics vs intracameral mydriatics

Mean pupillary diameter—at the beginning of cataract surgery (mm) · patients undergoing cataract surgery

1 finding from 1 review

Pharmacologic interventions for mydriasis in cataract surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 242 participants
Low