Cochrane · systematic review · CD012830
Pharmacologic interventions for mydriasis in cataract surgery
Iftikhar, M, Abariga, SA, Hawkins, BS, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
25
current version
GRADE rated
18
No studies
7
Included studies
NR
No studies 7 · 28%Ungraded 0 · 0%Very low 8 · 32%Low 9 · 36%Moderate 1 · 4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical mydriatics compared to intracameral mydriatics for mydriasis in cataract surgery
Population: patients undergoing cataract surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) Topical mydriatics vs intracameral mydriatics | no estimate extracted | 4 studies · 757 participants | Low Downgraded: risk of bias, imprecision |
Mean pupillary diameter—at the beginning of cataract surgery (mm) Topical mydriatics vs intracameral mydriatics | no estimate extracted | 4 studies · 242 participants | Low Downgraded: risk of bias, inconsistency |
Mean pupillary diameter—at the end of cataract surgery (mm) Topical mydriatics vs intracameral mydriatics | no estimate extracted | 5 studies · 799 participants | Low Downgraded: risk of bias, inconsistency |
Total intraoperative surgical time (min) Topical mydriatics vs intracameral mydriatics | no estimate extracted | 5 studies · 817 participants | Low Downgraded: risk of bias, imprecision |
Total time it took for the surgeon to perform phacoemulsification (seconds) Topical mydriatics vs intracameral mydriatics | no estimate extracted | 2 studies · 48 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
AE: participant‐reported ocular discomfort—week 1 Topical mydriatics vs intracameral mydriatics | RR 10.57 [1.37, 81.34] | 1 study · 555 participants | Very low Downgraded: risk of bias, imprecision |
AE: participant‐reported ocular discomfort—month 1 Topical mydriatics vs intracameral mydriatics | RR 2.51 [1.36, 4.65] | 1 study · 543 participants | Moderate Downgraded: risk of bias |
AE: posterior capsule rupture Topical mydriatics vs intracameral mydriatics | RR 0.32 [0.01, 7.83] | 1 study · 555 participants | Low Downgraded: risk of bias, imprecision |
AE: posterior capsule rupture—any time point during or after surgery Topical mydriatics vs intracameral mydriatics | RR 0.32 [0.01, 7.83] | 1 study · 555 participants | Low Downgraded: risk of bias, imprecision |
AE: cystoid macular edema Topical mydriatics vs intracameral mydriatics | RR 0.32 [0.01, 7.83] | 1 study · 555 participants | Low Downgraded: risk of bias, imprecision |
AE: cystoid macular edema ‐ any time point during or after surgery Topical mydriatics vs intracameral mydriatics | RR 0.32 [0.01, 7.83] | 1 study · 555 participants | Low Downgraded: risk of bias, imprecision |
Topical mydriatics compared to depot delivery systems for mydriasis in cataract surgery
Population: patients undergoing cataract surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) Topical mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
Mean pupillary diameter—at the beginning of cataract surgery (mm) Topical mydriatics vs depot delivery systems | no estimate extracted | 5 studies · 324 participants | Low Downgraded: risk of bias, inconsistency |
Mean pupillary diameter—at the end of cataract surgery (mm) Topical mydriatics vs depot delivery systems | no estimate extracted | 3 studies · 210 participants | Very low Downgraded: risk of bias, inconsistency |
Intraoperative surgical time—total intraoperative time (min) Topical mydriatics vs depot delivery systems | no estimate extracted | 1 study · 58 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
AE: participant‐reported ocular discomfort—week 1 Topical mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
AE: participant‐reported ocular discomfort—month 1 Topical mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
AE: vitreous loss—any time point during or after surgery Topical mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
Intracameral mydriatics compared to depot delivery systems for mydriasis in cataract surgery
Population: patients undergoing cataract surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean pupillary diameter—at the time the surgeon performs capsulorhexis (mm) Intracameral mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
Mean pupillary diameter—at the beginning of cataract surgery (mm) Intracameral mydriatics vs depot delivery systems | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Mean pupillary diameter—at the end of cataract surgery (mm) Intracameral mydriatics vs depot delivery systems | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Intraoperative surgical time—total intraoperative time (min) Intracameral mydriatics vs depot delivery systems | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
AE: participant‐reported ocular discomfort—week 1 Intracameral mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
AE: participant‐reported ocular discomfort—month 1 Intracameral mydriatics vs depot delivery systems | no estimate extracted | NR | No studies |
Adverse events Intracameral mydriatics vs depot delivery systems | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |