Cochrane · systematic review · CD010117
Propionyl‐L‐carnitine for intermittent claudication
Kamoen, V, Vander Stichele, R, Campens, L, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
8
No studies
4
Included studies
NR
No studies 4 · 33.3%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 25%Moderate 5 · 41.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Propionyl‐L‐carnitine compared to placebo for intermittent claudication
Population: people with intermittent claudication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absolute claudication distance (MWD + PWT) (in meters) Propionyl‐L‐carnitine vs placebo | no estimate extracted | 9 studies · 1121 participants | Moderate Downgraded: inconsistency, publication bias |
Initial claudication distance (PFWD + COT) (in meters) Propionyl‐L‐carnitine vs placebo | no estimate extracted | 9 studies · 1151 participants | Moderate Downgraded: inconsistency, publication bias |
Quality of life Propionyl‐L‐carnitine vs placebo | no estimate extracted | 1 study · 126 participants | Moderate Downgraded: imprecision |
Progression of disease (to Fontaine stage III or IV, or necessity for intervention (endovascular or surgery)) Propionyl‐L‐carnitine vs placebo | no estimate extracted | 1 study · 485 participants | Low Downgraded: imprecision |
Side effects of propionyl‐L‐carnitine regimen Propionyl‐L‐carnitine vs placebo | no estimate extracted | 6 studies · 1303 participants | Moderate |
Ankle brachial index (ABI) Propionyl‐L‐carnitine vs placebo | no estimate extracted | 4 studies · 369 participants | Moderate Downgraded: imprecision |
Propionyl‐L‐carnitine compared to L‐carnitine for intermittent claudication
Population: people with intermittent claudication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absolute claudication distance (in meters) Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Initial claudication distance (in meters) Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | 1 study · 28 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | NR | No studies |
Progression of disease (to Fontaine stage III or IV or necessity for intervention (endovascular or surgery)) Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | NR | No studies |
Side effects of propionyl‐L‐carnitine regimen Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | NR | No studies |
Ankle brachial index Propionyl‐L‐carnitine vs L‐carnitine | no estimate extracted | NR | No studies |