Findings

What do systematic reviews say?

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Chronic disease management vs usual care

Asthma severity score5 Measured on different scales in different studies. Higher scores indicate lower severity · adults with asthma

1 finding from 1 review

Chronic disease management programmes for adults with asthma 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1330 participants
Low

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: lower tidal volume ventilationAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: lower tidal volume… compared with supine (moderate certainty).

1 finding from 1 review

Prone position for acute respiratory failure in adults 2015 · Cochrane Headline outcomes only
RR 0.73 [0.55, 0.96]
5 studies · 911 participants
Moderate

Intervention not reported

Health‐related quality of life (disease‐specific) Scale from 0 to 100; lower score indicates better HRQoL. SGRQ total score consists of weighted scores from 3 domains · individuals with stable bronchiectasis

1 finding from 1 review

Airway clearance techniques for bronchiectasis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Intervention not reported

Respiratory symptoms (symptoms) Breathlessness, Cough and Sputum Scale Scale from 0 to 12. Lower score indicates fewer symptoms · individuals with stable bronchiectasis

The intervention showed no clear difference in respiratory symptoms (symptoms) Breathlessness, Cough and Sputum… (low certainty).

1 finding from 1 review

Airway clearance techniques for bronchiectasis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Any growth factor vs placebo or no growth factor

Lower limb amputation (minimum of one toe) · people with diabetes and foot ulcers

It is very uncertain whether any growth factor changes lower limb amputation (minimum of one toe) compared with placebo or no growth factor (very low certainty).

1 finding from 1 review

Growth factors for treating diabetic foot ulcers 2015 · Cochrane Headline outcomes only
RR 0.74 [0.39, 1.39]
2 studies · 219 participants
Very low

Etanercept vs placebo

CDLQI Scores range from 0 to 30. Lower scores indicate better health‐related quality of life. Calculations are based on the change from baseline to week 12 in both groups · people with paediatric psoriasis

1 finding from 1 review

Anti‐TNF agents for paediatric psoriasis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 211 participants
Moderate

Summary of findings table 4: refining rehabilitation: three months of postoperative night splinting with hand therapy vs hand therapy alone

Total active flexion at three months Major outcome group 5 (adverse effects) Total active flexion (TAF) of MCPJ, PIPJ and DIPJ; lower value indicates loss of flexion and a worse outcome · 210 participants with Dupuytren's disease of the fingers in 2 studies (225 digits reported across all studies) (Collis 2013;…

1 finding from 1 review

Surgery for Dupuytren's contracture of the fingers 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 225 participants
Low

Intervention not reported

Pain (at study completion) WOMAC (VAS or NRS) from 0 to 20; lower scores mean reduced pain · People with hip or knee osteoarthritis

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 313 participants
Low

Intervention not reported

Physical function (at study completion) WOMAC (self administered health status measure) from 0 to 68; lower scores mean better function · People with hip or knee osteoarthritis

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 310 participants
Low

Parent‐infant psychotherapy vs control

Depression (lower scores mean less depression) · participants with improving parental and infant mental health

1 finding from 1 review

Parent‐infant psychotherapy for improving parental and infant mental health 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 356 participants
Low

Parent‐infant psychotherapy vs other (psychoeducational) parenting intervention: parent mental health and infant attachment

Depression (lower scores mean less depression) · participants with improving parental and infant mental health

1 finding from 1 review

Parent‐infant psychotherapy for improving parental and infant mental health 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 172 participants
Very low

Intervention not reported

Fatigue (lower scores mean less fatigue) · Patients with fibromyalgia

1 finding from 1 review

Selective serotonin reuptake inhibitors for fibromyalgia syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 192 participants
Very low

Intervention not reported

Sleep problems (lower scores mean less sleep problems) · Patients with fibromyalgia

1 finding from 1 review

Selective serotonin reuptake inhibitors for fibromyalgia syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 193 participants
Very low

Intervention not reported

Depression (lower scores mean less depression) · Patients with fibromyalgia

1 finding from 1 review

Selective serotonin reuptake inhibitors for fibromyalgia syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 244 participants
Very low

Parent‐only interventions vs waiting list control

Parent‐child relationship or assessment of parenting · children with overweight or obesity

1 finding from 1 review

Parent‐only interventions for childhood overweight or obesity in children aged 5 to 11 years 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Duration of grade IV neutropenia (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in duration of grade IV neutropenia (lower values signify better… compared with antibiotics alone (low certainty).

1 finding from 1 review

Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 1135 participants
Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to recovery from fever (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to recovery from fever (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 966 participants
Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to withdrawal from ATB (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to withdrawal from ATB (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 457 participants
Low

Preoperative education vs usual care

Pain intensity (0‐10cm visual analogue scale) · hip replacement

1 finding from 1 review

Preoperative education for hip or knee replacement 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 227 participants
Low

Preoperative education vs usual care

Physical function · hip replacement

1 finding from 1 review

Preoperative education for hip or knee replacement 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 177 participants
Low