Any growth factor vs placebo or no growth factor: Lower limb amputation (minimum of one toe)
It is very uncertain whether any growth factor changes lower limb amputation (minimum of one toe) compared with placebo or no growth factor (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Any growth factor vs placebo or no growth factor Lower limb amputation (minimum of one toe) · foot ulcers in people with diabetes It is very uncertain whether any growth factor changes lower limb amputation (minimum of one toe) compared with placebo or no growth factor (very low certainty). Growth factors for treating diabetic foot ulcers (2015) · Cochrane Headline outcomes only | RR 0.74 [0.39, 1.39] | 2 studies · 219 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Growth factors for treating diabetic foot ulcers 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.