evidence/gaps
Cochrane · systematic review · CD008548

Growth factors for treating diabetic foot ulcers

Martí‐Carvajal, AJ, Gluud, C, Nicola, S, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library

WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 50%Very low 1 · 16.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Any growth factor compared with placebo or no growth factor for diabetic foot ulcer

Population: foot ulcers in people with diabetes
6 questions
OutcomeEffectEvidenceStatus / GRADE
Complete wound closure
Any growth factor vs placebo or no growth factor
RR 1.51 [1.31, 1.73]12 studies · 1316 participantsLow
Downgraded: risk of bias, inconsistency
Lower limb amputation (minimum of one toe)
Any growth factor vs placebo or no growth factor
RR 0.74 [0.39, 1.39]2 studies · 219 participantsVery low
Downgraded: risk of bias, imprecision
Ulcer‐free days following treatment for diabetic foot ulcers (free from any recurrence)
Any growth factor vs placebo or no growth factor
no estimate extracted1 study · 55 participantsUngraded
Time to complete healing of the diabetic foot ulcer
Any growth factor vs placebo or no growth factor
no estimate extracted0 studies · 0 participantsUngraded
Quality of life
Any growth factor vs placebo or no growth factor
no estimate extracted0 studies · 0 participantsUngraded
Adverse events (non‐serious and serious)
Any growth factor vs placebo or no growth factor
RR 0.98 [0.79, 1.22]4 studies · 385 participantsLow
Downgraded: risk of bias, imprecision