Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

966 questions · 1,015 findings · 90 reviews · Headline outcomes only

No studies found 256 · 25.2%GRADE not reported 62 · 6.1%Very low 271 · 26.7%Low 269 · 26.5%Moderate 111 · 10.9%High 46 · 4.5%

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Mortality during intervention · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with as a supplement to the usual diet (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…
1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Stillbirth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in stillbirth compared with placebo, no placebo or other supplements (moderate certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Preterm birth · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Pre‐eclampsia · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in clinical pre‐eclampsia (random‐effects model) compared with placebo, no placebo or other supplements (moderate certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Intrauterine growth restriction · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in intrauterine growth restriction (various definitions) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Preterm prelabour rupture of membranes · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation showed no clear difference in prelabour rupture of fetal membranes ‐ preterm compared with placebo, no placebo or other supplements (low certainty).

1 finding from 1 review

Vitamin E vs placebo, no placebo or other supplements

Bleeding episodes (placental abruption) · pregnant women receiving vitamin E supplementation or control, living in areas where there is either inadequate dietary intake of vitamin…

Any vitamin E supplementation leads to lower bleeding episodes (placental abruption) compared with placebo, no placebo or other supplements (high certainty).

1 finding from 1 review

Intervention not reported

Stillbirth · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in stillbirth (moderate certainty).

1 finding from 1 review

Intervention not reported

Intrauterine growth restriction · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in intrauterine growth restriction (high certainty).

1 finding from 1 review

Intervention not reported

Preterm birth (< 37 weeks' gestation) · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in preterm birth (< 37 weeks' gestation) (high certainty).

1 finding from 1 review

Intervention not reported

Preterm prelabour rupture of membranes · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in preterm prelabour rupture of membranes (low certainty).

1 finding from 1 review

Intervention not reported

Clinical pre‐eclampsia · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention showed no clear difference in clinical pre‐eclampsia (moderate certainty).

1 finding from 1 review

Intervention not reported

Placental abruption · All pregnant women receiving either vitamin C supplementation or control either in areas where there is inadequate dietary intake or where…

The intervention leads to lower placental abruption (high certainty).

1 finding from 1 review