Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Intraoperative neuromonitoring vs visual nerve identification only during thyroidectomy

Permanent RILN palsy (nerves) Definition: injury detected clinically, by laryngoscopy or both, in which the motility of the vocal cords did not recover within 6 months after surgery

It is very uncertain whether intraoperative neuromonitoring changes permanent RILN palsy (nerves) Definition: injury detected… compared with visual nerve identification only during thyroidectomy (very low certainty).

1 finding from 1 review

Intraoperative neuromonitoring vs visual nerve identification only during thyroidectomy

Transient RILN palsy (nerves) Definition: injury detected clinically, by laryngoscopy or both, in which the motility of the vocal cords recovered within 6 months after surgery

It is very uncertain whether intraoperative neuromonitoring changes transient RILN palsy (nerves) Definition: injury detected… compared with visual nerve identification only during thyroidectomy (very low certainty).

1 finding from 1 review