Cochrane · systematic review · CD013584
Effects of interventions targeting the systemic inflammatory response to cardiac surgery on clinical outcomes in adults
Abbasciano, RG, Tomassini, S, Roman, MA, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table for pooled treatment effects of the three categories of inflammatory intervention against control
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Peak IL‐6 (between the end of surgery and 24 hours post‐surgery) | no estimate extracted | 152 studies · 6485 participants | Very low |
Peak IL‐8 (between the end of surgery and 6 hours post‐surgery) | no estimate extracted | 72 studies · 2963 participants | Very low |
Hospital or 30‐day mortality | RR 0.78 [0.68, 0.91] | 190 studies · 24817 participants | Very low |
Myocardial injury (hospital stay) | RR 1.04 [0.95, 1.14] | 86 studies · 23118 participants | Very low |
Kidney injury (safety outcome) (hospital stay) | RR 1.06 [0.96, 1.16] | 79 studies · 23103 participants | Low |
Surgical Site Infection (hospital stay) | RR 0.92 [0.83, 1.01] | 40 studies · 19368 participants | Low |
Duration of hospital length of stay | no estimate extracted | 148 studies · 15547 participants | Very low |