Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy
In one RCT, preformed metal crowns had an annual failure rate of 2.5% after 2 years.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Negative oral-health impact on daily performance (OIDP or Child-OIDP) · Adolescents (10-19 years)
In the Child-OIDP subgroup, dental caries is associated with a worse oral-health impact: PR 1.66 (95% CI 1.19 to 2.31) from 6 studies (I2=96%); ungraded, and not statistically different from the OIDP subgroup (p=0.96).
5 findings from 1 review
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: Child-OIDP
PR 1.66 [1.19, 2.31]
6 studies
GRADE not reported
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: OIDP (all 3 studies)
PR 1.68 [0.89, 3.17]
3 studies
GRADE not reported
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: OIDP, sensitivity analysis excluding Krisdapong et al.
PR 1.21 [1.15, 1.28]
2 studies
GRADE not reported
Show 2 more findings
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Overall (all meta-analyzed studies pooled; both instruments and both caries definitions)
PR 1.52 [1.15, 2.01]
9 studies
GRADE not reported
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Caries-definition subgroup: presence of dental caries
PR 1.19 [0.77, 1.84]
3 studies
GRADE not reported
Oral health-related quality of life · people aged 60 years and older living in the community
No statistically significant difference in OHRQoL was reported by edentulism prevalence.
1 finding from 1 review
Oral health-related quality of life · people aged 60 years and older living in the community
No statistically significant difference in OHRQoL was reported by edentulism prevalence.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.5%) in primary molars after pulpotomy, but the evidence is of low quality (single high-risk-of-bias split-mouth RCT; not GRADE-rated).
2 findings from 1 review
Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
The review found no eligible studies for this question.
1 finding from 1 review
Change in feeling of dryness · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
The review found no eligible studies for this question.
1 finding from 1 review
Oral health-related quality of life · people aged 60 years and older living in the community
The review reported higher OHRQoL in the low than high dental-caries-prevalence category.
1 finding from 1 review
71.40 [64.16, 78.63]
Studies not reported
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
Periodontal disease was associated with higher odds of poor OHRQoL (OR 1.15, 95% CI 1.12-1.18; 3 studies; no heterogeneity; ungraded).
1 finding from 1 review
OR 1.15 [1.12, 1.18]
3 studies
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, presence of the third molar increases odds of spontaneous space closure (OR 2.28; low certainty).
1 finding from 1 review
Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
Pre-drilling mini-screw implant showed no clear difference in success of the anchorage device compared with self-drilling mini-screw implant; GRADE not reported.
1 finding from 1 review
Patient perception: pain · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
1 finding from 1 review
Self-reported pain on insertion (0-4 scale): pre-drilling mean 0.73 (SD 1.1; median 0.00, IQR 0-3) vs self-drilling mean 1.87 (SD 1.13; median 2.0, IQR 0-4); 1 study (Lehnen 2011), 30 participants
1 study · 30 participants
GRADE not reported
Clinical response (not analysable) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
Oral health (dentition and gingival scores) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Poland 1987 (crossover, high risk of bias, n=20): CMC/sorbitol reported superior to lemon glycerin for reducing oral dryness; brief report, incomplete data, period effect noted; not usable for meta-analysis.
1 study · 20 participants
GRADE not reported
Completion of dental treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Intraoperative pain · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
1 finding from 1 review
pain (SEM scale); risk with conventional treatment -, risk with pre-cooling -; 160 (1 RCT); VERY LOW. Evidence is uncertain regarding the effect of pre-cooling of the injection site on pain (data presented in a form…
1 study · 160 participants
Very low
Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review