Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Angiotensin‐converting enzyme inhibitors vs ARB

Total mortality · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total mortality compared with all angiotensin receptor blockers (ARBs) (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Cardiovascular events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total cardiovascular events compared with all angiotensin receptor blockers (ARBs) (low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Withdrawals due to adverse events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors leads to lower withdrawal due to adverse effects compared with all angiotensin receptor blockers (ARBs) (high certainty).

1 finding from 1 review

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Patients free of RRT after discontinuing CRRT · AKI

Intensive showed no clear difference in patients free of RRT after discontinuing CRRT compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

2 findings from 1 review

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Mortality: patients with AKI related to cardiac or general surgery · patients with AKI who need CRRT

Intensive leads to lower mortality: patients with AKI related to cardiac or general surgery compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

1 finding from 1 review

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Mortality: patients with AKI not related to surgery · patients with AKI who need CRRT

Intensive showed no clear difference in mortality: patients with AKI not related to surgery compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

1 finding from 1 review

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (maternal outcomes)

Hypertensive disorders of pregnancy · women with gestational diabetes mellitus

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with less‐tight glycaemic targets (maternal outcomes) (low certainty).

1 finding from 1 review