Cochrane · systematic review · CD010613
Intensity of continuous renal replacement therapy for acute kidney injury
Fayad, AI, Buamscha, DG, Ciapponi, A · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 66.7%Moderate 1 · 11.1%High 2 · 22.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intensive versus less intensive continuous renal replacement therapy (CRRT) for acute kidney injury (AKI)
Population: patients with AKI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at day 30 Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.88 [0.81, 1.1] | 5 studies · 2402 participants | Low |
Mortality after 30 days post‐randomisation Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.92 [0.8, 1.06] | 5 studies · 2759 participants | Low |
Patients free of RRT after discontinuing CRRT Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 1.12 [0.91, 1.37] | 5 studies · 2402 participants | Low |
Patients free of RRT after discontinuing CRRT Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.98 [0.94, 1.01] | 3 studies · 988 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Adverse events: hypophosphataemia Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 1.21 [1.11, 1.31] | 1 study · 1441 participants | High |
Intensive versus less intensive continuous renal replacement therapy (CRRT) for acute kidney injury (AKI): subgroups
Population: patients with AKI who need CRRT
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality: patients with sepsis Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.94 [0.69, 1.27] | 5 studies · 966 participants | Low |
Mortality: patients without sepsis Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.89 [0.69, 1.15] | 4 studies · 1216 participants | Low |
Mortality: patients with AKI related to cardiac or general surgery Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.73 [0.61, 0.88] | 2 studies · 531 participants | High |
Mortality: patients with AKI not related to surgery Intensive vs less intensive continuous renal replacement therapy (CRRT) | RR 0.94 [0.73, 1.2] | 3 studies · 1871 participants | Low |