Cochrane · systematic review · CD000028
Pharmacotherapy for hypertension in adults 60 years or older
Musini, VM, Tejani, AM, Bassett, K, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 1 · 20%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsAntihypertensive drug compared to placebo or no treatment in adults 60 years or older
Population: adults 60 years or older with primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Mean duration of 3.8 years Antihypertensive drug vs placebo or no treatment | RR 0.91 [0.85, 0.97] | 13 studies · 25932 participants | High |
Cardiovascular mortality and morbidity Mean duration of 3.7 years Antihypertensive drug vs placebo or no treatment | RR 0.72 [0.68, 0.77] | 15 studies · 26747 participants | Moderate Downgraded: risk of bias |
Cerebrovascular mortality and morbidity Mean duration of 3.7 years Antihypertensive drug vs placebo or no treatment | RR 0.66 [0.59, 0.74] | 13 studies · 26042 participants | Moderate Downgraded: risk of bias |
Coronary heart disease mortality and morbidity Mean duration of 2.9 years Antihypertensive drug vs placebo or no treatment | RR 0.78 [0.69, 0.88] | 11 studies · 24559 participants | Moderate Downgraded: risk of bias |
Withdrawals due to adverse effects Mean duration of 4.6 years Antihypertensive drug vs placebo or no treatment | RR 2.91 [2.56, 3.3] | 4 studies · 11310 participants | Low Downgraded: risk of bias, inconsistency |