Cochrane · systematic review · CD000028

Pharmacotherapy for hypertension in adults 60 years or older

Musini, VM, Tejani, AM, Bassett, K, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

Hypertension2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 1 · 20%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Antihypertensive drug compared to placebo or no treatment in adults 60 years or older

Population: adults 60 years or older with primary hypertension

CD000028.PUB3 (current) · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Total mortality Mean duration of 3.8 years Antihypertensive drug vs placebo or no treatment	RR 0.91 [0.85, 0.97]	13 studies · 25932 participants	High
Cardiovascular mortality and morbidity Mean duration of 3.7 years Antihypertensive drug vs placebo or no treatment	RR 0.72 [0.68, 0.77]	15 studies · 26747 participants	Moderate Downgraded: risk of bias
Cerebrovascular mortality and morbidity Mean duration of 3.7 years Antihypertensive drug vs placebo or no treatment	RR 0.66 [0.59, 0.74]	13 studies · 26042 participants	Moderate Downgraded: risk of bias
Coronary heart disease mortality and morbidity Mean duration of 2.9 years Antihypertensive drug vs placebo or no treatment	RR 0.78 [0.69, 0.88]	11 studies · 24559 participants	Moderate Downgraded: risk of bias
Withdrawals due to adverse effects Mean duration of 4.6 years Antihypertensive drug vs placebo or no treatment	RR 2.91 [2.56, 3.3]	4 studies · 11310 participants	Low Downgraded: risk of bias, inconsistency

Antihypertensive drug therapy compared to control in elderly (60 years or older) for hypertension in the elderly

Population: patients with hypertension in the elderly

CD000028.PUB2 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Total mortality ‐ Elderly 60 years or older Antihypertensive drug therapy vs control	RR 0.9 [0.84, 0.97]	12 studies · 23119 participants	Low Downgraded: imprecision
Cardiovascular mortality and morbidity ‐ Elderly 60 years or older Antihypertensive drug therapy vs control	RR 0.72 [0.68, 0.77]	13 studies · 23094 participants	High

Antihypertensive drug therapy compared to control in very elderly 80 years or older for hypertension

Population: patients with Elderly patients with primary hypertension

CD000028.PUB2 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Total mortality ‐ Very elderly 80 years or older Antihypertensive drug therapy vs control	RR 0.98 [0.87, 1.1]	8 studies · 6701 participants	Low Downgraded: inconsistency
Cardiovascular mortality and morbidity ‐ Very elderly 80 years or older Antihypertensive drug therapy vs control	RR 0.75 [0.65, 0.87]	7 studies · 6546 participants	Moderate Downgraded: imprecision