Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with NIPPV or NIV (low certainty).
1 finding from 1 review
Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support
nHFV showed no clear difference in mortality before hospital discharge compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).
1 finding from 1 review
Endotracheal intubation To discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support
It is very uncertain whether nHFV changes endotracheal intubation To discharge compared with nIPPV following failure of initial non‐invasive respiratory support (very low certainty).
1 finding from 1 review
Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support
nHFV showed no clear difference in chronic lung disease compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).
1 finding from 1 review
Death or chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support
1 finding from 1 review
Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support
nHFV showed no clear difference in intraventricular haemorrhage, Papile grade 3/4 compared with nIPPV following failure of initial non‐invasive respiratory support (low certainty).
1 finding from 1 review
Neurodevelopmental disability · ventilated preterm infants with failure of initial non‐invasive respiratory support
1 finding from 1 review
Failure of modality · preventing respiratory failure in preterm infants
It is very uncertain whether diaphragm‐triggered non‐invasive changes failure of modality compared with other non‐invasive respiratory support (very low certainty).
1 finding from 1 review
Chronic lung disease · preventing respiratory failure in preterm infants
1 finding from 1 review
Mortality before hospital discharge · preventing respiratory failure in preterm infants
1 finding from 1 review
Intervention not reported
Duration of ventilatory support (days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome
1 finding from 1 review
Treatment failure (death or use of additional ventilatory support) · preterm infants with respiratory distress for initial respiratory support
It is very uncertain whether CPAP changes treatment failure (death or use of additional ventilatory support) compared with supplemental oxygen (very low certainty).
1 finding from 1 review
Intervention not reported
Requirement for inotropic support (scale from 0 to 28, days of catecholamine use) · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
1 finding from 1 review
Duration of invasive ventilatory support · preterm infants < 37 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome
1 finding from 1 review
Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in treatment failure within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).
1 finding from 1 review
Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with nasal intermittent positive pressure ventilation (moderate certainty).
1 finding from 1 review
Pneumothorax · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in pneumothorax (during assigned treatment) compared with nasal intermittent positive pressure ventilation (moderate certainty).
1 finding from 1 review
Nasal trauma (during assigned treatment) · preterm infants requiring primary respiratory support
Nasal high flow probably leads to lower nasal trauma (during assigned treatment) compared with nasal intermittent positive pressure ventilation (moderate certainty).
1 finding from 1 review
Mortality before hospital discharge · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in death (before hospital discharge) compared with continuous positive airway pressure (low certainty).
1 finding from 1 review
Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support
Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).
1 finding from 1 review