Cochrane · systematic review · CD012712
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress
Abdel-Latif, ME, Tan, O, Fiander, M, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
42
current version
GRADE rated
31
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 11 · 26.2%Very low 10 · 23.8%Low 14 · 33.3%Moderate 7 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
nHFV compared to invasive respiratory therapy for initial respiratory support
Population: preterm infants with respiratory distress
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs invasive respiratory therapy | RR 0.67 [0.2, 2.18] | 1 study · 80 participants | Very low Downgraded: risk of bias |
Endotracheal intubation or reintubation To discharge nHFV vs invasive respiratory therapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Chronic lung disease nHFV vs invasive respiratory therapy | RR 0.38 [0.09, 1.59] | 2 studies · 180 participants | Very low Downgraded: risk of bias |
Death or chronic lung disease nHFV vs invasive respiratory therapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs invasive respiratory therapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurodevelopmental disability nHFV vs invasive respiratory therapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV compared to nCPAP used for initial respiratory support
Population: newborn (term* and preterm) infants with respiratory distress for initial respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs nCPAP used | RR 1 [0.41, 2.41] | 4 studies · 531 participants | Very low Downgraded: risk of bias |
Endotracheal intubation To discharge nHFV vs nCPAP used | RR 0.52 [0.33, 0.82] | 5 studies · 571 participants | Low Downgraded: risk of bias |
Chronic lung disease nHFV vs nCPAP used | RR 1.35 [0.8, 2.27] | 4 studies · 481 participants | Low Downgraded: risk of bias |
Death or chronic lung disease nHFV vs nCPAP used | RR 2.5 [0.52, 12.01] | 1 study · 68 participants | Low Downgraded: risk of bias, imprecision |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs nCPAP used | RR 1.17 [0.36, 3.78] | 4 studies · 531 participants | Low Downgraded: risk of bias |
Neurodevelopmental disability nHFV vs nCPAP used | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV compared to nIPPV used for initial respiratory support
Population: preterm infants with respiratory distress for initial respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs nIPPV used | RR 1.86 [0.9, 3.83] | 2 studies · 84 participants | Low Downgraded: risk of bias |
Endotracheal intubation To discharge nHFV vs nIPPV used | RR 1.33 [0.76, 2.34] | 5 studies · 228 participants | Low Downgraded: risk of bias |
Chronic lung disease nHFV vs nIPPV used | RR 0.63 [0.42, 0.95] | 5 studies · 307 participants | Low Downgraded: risk of bias |
Death or chronic lung disease nHFV vs nIPPV used | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs nIPPV used | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias |
Neurodevelopmental disability nHFV vs nIPPV used | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV compared to HFNC for initial respiratory support
Population: preterm infants with respiratory distress for initial respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs HFNC | no estimate extracted | 1 study · 37 participants | Very low Downgraded: risk of bias |
Endotracheal intubation or reintubation To discharge nHFV vs HFNC | RR 2.94 [0.65, 13.27] | 1 study · 37 participants | Very low Downgraded: risk of bias |
Chronic lung disease nHFV vs HFNC | RR 1.18 [0.46, 2.98] | 1 study · 37 participants | Very low Downgraded: risk of bias |
Death or chronic lung disease nHFV vs HFNC | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs HFNC | no estimate extracted | 1 study · 37 participants | Very low Downgraded: risk of bias |
Neurodevelopmental disability nHFV vs HFNC | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV compared to nCPAP for respiratory support following planned extubation
Population: ventilated preterm infants with planned extubation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs nCPAP | RR 0.92 [0.52, 1.64] | 6 studies · 1427 participants | Moderate Downgraded: imprecision |
Endotracheal reintubation To discharge nHFV vs nCPAP | RR 0.42 [0.35, 0.51] | 11 studies · 1897 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Chronic lung disease nHFV vs nCPAP | RR 0.78 [0.67, 0.91] | 10 studies · 1829 participants | Low Downgraded: imprecision |
Death or chronic lung disease nHFV vs nCPAP | RR 0.9 [0.77, 1.06] | 2 studies · 966 participants | Moderate Downgraded: imprecision |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs nCPAP | RR 0.8 [0.57, 1.13] | 3 studies · 1117 participants | Moderate Downgraded: imprecision |
Neurodevelopmental disability nHFV vs nCPAP | RR 0.92 [0.37, 2.29] | 1 study · 74 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
nHFV compared to nIPPV for respiratory support following planned extubation
Population: ventilated preterm infants with planned extubation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs nIPPV | RR 1.83 [0.7, 4.79] | 2 studies · 984 participants | Low Downgraded: risk of bias |
Endotracheal reintubation To discharge nHFV vs nIPPV | RR 0.69 [0.54, 0.89] | 6 studies · 1364 participants | Moderate Downgraded: risk of bias |
Chronic lung disease nHFV vs nIPPV | RR 0.88 [0.75, 1.04] | 4 studies · 1236 participants | Moderate Downgraded: risk of bias, imprecision |
Death or chronic lung disease nHFV vs nIPPV | RR 0.92 [0.79, 1.08] | 3 studies · 1070 participants | Moderate Downgraded: risk of bias, imprecision |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs nIPPV | RR 0.78 [0.55, 1.1] | 4 studies · 1162 participants | Moderate Downgraded: risk of bias, imprecision |
Neurodevelopmental disability nHFV vs nIPPV | RR 0.88 [0.35, 2.16] | 1 study · 72 participants | Low Downgraded: risk of bias |
nHFV compared to nIPPV following failure of initial non‐invasive respiratory support
Population: ventilated preterm infants with failure of initial non‐invasive respiratory support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality before hospital discharge nHFV vs nIPPV following failure of initial non‐invasive respiratory support | RR 1.44 [0.1, 21.33] | 1 study · 39 participants | Low Downgraded: imprecision |
Endotracheal intubation To discharge nHFV vs nIPPV following failure of initial non‐invasive respiratory support | RR 1.23 [0.51, 2.98] | 1 study · 39 participants | Very low Downgraded: imprecision |
Chronic lung disease nHFV vs nIPPV following failure of initial non‐invasive respiratory support | RR 1.01 [0.7, 1.47] | 1 study · 39 participants | Low Downgraded: imprecision |
Death or chronic lung disease nHFV vs nIPPV following failure of initial non‐invasive respiratory support | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intraventricular haemorrhage, Papile grade 3/4 nHFV vs nIPPV following failure of initial non‐invasive respiratory support | RR 0.47 [0.02, 10.87] | 1 study · 39 participants | Low Downgraded: risk of bias, imprecision |
Neurodevelopmental disability nHFV vs nIPPV following failure of initial non‐invasive respiratory support | no estimate extracted | 0 studies · 0 participants | Ungraded |