Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomesshort-term (up to 3 months) · gabapentin with adjunctive ALA
SoF2 subgroup. Gabapentin + adjunctive ALA vs placebo forms one of two subgroups of the anticonvulsant symptom-relief estimate (RR 4.00, 2.09 to 7.67); no between-subgroup difference vs gabapentin alone; 100…
1 study · 40 participants
Very low
Additional drugs required to terminate the seizure: 2 or more additional anticonvulsants required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intranasal lorazepam may leads to lower additional drugs required to terminate the seizure: 2 or more… compared with intramuscular paraldehyde (low certainty).
1 finding from 1 review
Alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepine showed no clear difference in alcohol withdrawal seizures ‐ Benzodiazepine vs. Anticonvulsant compared with other Drug for (moderate certainty).
1 finding from 1 review
Adverse events ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepine showed no clear difference in adverse events ‐ Benzodiazepine vs. Anticonvulsant compared with other Drug for (high certainty).
1 finding from 1 review
Dropouts ‐ Benzodiazepine vs. Anticonvulsant · patients with
Benzodiazepine showed no clear difference in dropouts ‐ Benzodiazepine vs. Anticonvulsant compared with other Drug for (high certainty).
1 finding from 1 review
Occlusal splint vs Pharmacological interventions (benzodiazepines, anticonvulsants, beta blockers, dopamine agents, antidepressants, botulinum toxin A and B, analgesics)
Outcome not reported · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
The review found no eligible studies for this question.
1 finding from 1 review
Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV probably leads to lower non‐cessation of seizures compared with diazepam IV (moderate certainty).
1 finding from 1 review
Non‐cessation of seizures · patients with status epilepticus
Diazepam gel probably leads to lower non‐cessation of seizures compared with placebo gel (moderate certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
Diazepam gel showed no clear difference in adverse effects compared with placebo gel (moderate certainty).
1 finding from 1 review
Requirement for ventilatory support · patients with status epilepticus
Lorazepam IV showed no clear difference in requirement for ventilatory support compared with diazepam IV (low certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
1 finding from 1 review
Continuation of status requiring a different drug or general anaesthesia · patients with status epilepticus
Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).
1 finding from 1 review
Death · patients with status epilepticus
1 finding from 1 review
Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV showed no clear difference in non‐cessation of seizures compared with diazepam plus phenytoin IV (low certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
Lorazepam IV showed no clear difference in adverse effects compared with diazepam plus phenytoin IV (moderate certainty).
1 finding from 1 review
Deaths · patients with status epilepticus
1 finding from 1 review
Requirement for ventilatory support · patients with status epilepticus
1 finding from 1 review
At least 50% reduction in pain · patients with fibromyalgia
Pregabalin leads to higher 50% pain reduction compared with placebo at end of treatment (high certainty).
1 finding from 1 review
Patient Global Impression of Change much or very much improved · patients with fibromyalgia
Pregabalin leads to higher patient Global Impression of Change of 'much' or 'very much' improved compared with placebo at end of treatment (high certainty).
1 finding from 1 review
Fatigue · patients with fibromyalgia
1 finding from 1 review