Cochrane · systematic review · CD003723
Anticonvulsant therapy for status epilepticus
Prasad, M, Krishnan, PR, Sequeira, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 18.2%Very low 1 · 9.1%Low 2 · 18.2%Moderate 6 · 54.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Lorazepam IV versus diazepam IV for status epilepticus
Population: patients with status epilepticus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Non‐cessation of seizures Lorazepam IV vs diazepam IV | RR 0.64 [0.45, 0.9] | 3 studies · 264 participants | Moderate Downgraded: risk of bias |
Requirement for ventilatory support Lorazepam IV vs diazepam IV | RR 0.73 [0.36, 1.49] | 3 studies · 264 participants | Low Downgraded: risk of bias |
Adverse effects Lorazepam IV vs diazepam IV | no estimate extracted | 3 studies · 264 participants | Very low |
Continuation of status requiring a different drug or general anaesthesia Lorazepam IV vs diazepam IV | RR 0.63 [0.45, 0.88] | 3 studies · 264 participants | Moderate |
Death Lorazepam IV vs diazepam IV | no estimate extracted | 2 studies · 203 participants | Moderate Downgraded: risk of bias |
Lorazepam IV versus diazepam plus phenytoin IV for status epilepticus
Population: patients with status epilepticus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Non‐cessation of seizures Lorazepam IV vs diazepam plus phenytoin IV | no estimate extracted | 2 studies · 370 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects Lorazepam IV vs diazepam plus phenytoin IV | RR 0.85 [0.63, 1.15] | 2 studies · 370 participants | Moderate Downgraded: risk of bias, imprecision |
Deaths Lorazepam IV vs diazepam plus phenytoin IV | no estimate extracted | 1 study · 178 participants | Ungraded |
Requirement of Ventilatory support Lorazepam IV vs diazepam plus phenytoin IV | no estimate extracted | 1 study · 178 participants | Ungraded |
Diazepam gel versus placebo gel for status epilepticus
Population: patients with status epilepticus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Non‐cessation of seizures Diazepam gel vs placebo gel | RR 0.43 [0.3, 0.62] | 2 studies · 165 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse effects Diazepam gel vs placebo gel | RR 1.5 [0.94, 2.37] | 2 studies · 165 participants | Moderate Downgraded: risk of bias, imprecision |