Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 65 findings · 12 reviews

No studies found 4 · 6.2%GRADE not reported 6 · 9.2%Very low 13 · 20%Low 10 · 15.4%Moderate 24 · 36.9%High 8 · 12.3%

Anticonvulsant vs placebo

Alcohol Withdrawal Seizures post treatment ‐ Any Anticonvulsant vs. Placebo · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol Withdrawal Seizures post treatment ‐ Any Anticonvulsant vs.… compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Alcohol withdrawal seizures ‐ Any Anticonvulsant vs any Other · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol withdrawal seizures ‐ Any Anticonvulsant vs any Other compared with other Drugs (low certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Adverse events ‐ Any Anticonvulsant vs any Other · people with alcohol withdrawal

Anticonvulsant showed no clear difference in adverse events ‐ Any Anticonvulsant vs any Other compared with other Drugs (moderate certainty).

1 finding from 1 review

Anticonvulsant vs other drugs

Leaving the study early · people with alcohol withdrawal

Anticonvulsant showed no clear difference in dropout ‐ Any Anticonvulsant vs any Other compared with other Drugs (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Alcohol Withdrawal Seizures post treatment ‐ Phenytoin vs. Placebo · people with alcohol withdrawal

Anticonvulsant showed no clear difference in alcohol Withdrawal Seizures post treatment ‐ Phenytoin vs. Placebo compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events · people with alcohol withdrawal

Anticonvulsant showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Leaving the study early · patients with alcohol dependence

Anticonvulsants showed no clear difference in dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Continuous abstinence rate at · patients with alcohol dependence

Anticonvulsants showed no clear difference in continuous abstinence compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with alcohol dependence

Anticonvulsants showed no clear difference in adverse events—withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Dropout · patients with cocaine dependence

Any anticonvulsant showed no clear difference in dropout Number of participants who did not complete the treatment compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Number of participants using cocaine during the treatment (as days/week by urine tests or self report) Number of participants that reported the use of cocaine during the treatment · patients with cocaine dependence

Any anticonvulsant showed no clear difference in use of cocaine (self reported or objective) Number of participants… compared with placebo (moderate certainty).

1 finding from 1 review

Anticonvulsant vs placebo

Participants with at least some Side Effects · patients with cocaine dependence

Any anticonvulsant may leads to higher side effect Number of participants reporting at least 1 side effect… compared with placebo (low certainty).

1 finding from 1 review

Gabapentin vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Gabapentin vs placebo

Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Gabapentin vs placebo

Change in feeling of dryness · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review