Cochrane · systematic review · CD006754
Anticonvulsants for cocaine dependence
Minozzi, S, Cinquini, M, Amato, L, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any anticonvulsant versus placebo for cocaine dependence
Population: patients with cocaine dependence
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dropout Number of participants who did not complete the treatment Any anticonvulsant vs placebo | RR 0.95 [0.86, 1.05] | 17 studies · 1695 participants | Moderate Downgraded: risk of bias |
Use of cocaine (self reported or objective) Number of participants who reported the use of cocaine during treatment, and/or number of participants with urine samples positive for cocaine Any anticonvulsant vs placebo | RR 0.92 [0.84, 1.02] | 9 studies · 867 participants | Moderate Downgraded: risk of bias |
Side effect Number of participants reporting at least 1 side effect and types of side effects experienced during treatment Any anticonvulsant vs placebo | RR 1.39 [1.01, 1.9] | 8 studies · 775 participants | Low Downgraded: risk of bias, imprecision |
Craving (BSCS) Measured by validated scales (e.g. Brief Substance Craving Scale (BSCS)) Any anticonvulsant vs placebo | no estimate extracted | 7 studies · 428 participants | Low Downgraded: risk of bias |